Therapeutic Applications of Halloysite
In recent years, nanomaterials have attracted significant research interest for applications in biomedicine. Many kinds of engineered nanomaterials, such as lipid nanoparticles, polymeric nanoparticles, porous nanomaterials, silica, and clay nanoparticles, have been investigated for use in drug deli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/1/87 |
| _version_ | 1797499683700998144 |
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| author | Mohammadmahdi Mobaraki Sonali Karnik Yue Li David K. Mills |
| author_facet | Mohammadmahdi Mobaraki Sonali Karnik Yue Li David K. Mills |
| author_sort | Mohammadmahdi Mobaraki |
| collection | DOAJ |
| description | In recent years, nanomaterials have attracted significant research interest for applications in biomedicine. Many kinds of engineered nanomaterials, such as lipid nanoparticles, polymeric nanoparticles, porous nanomaterials, silica, and clay nanoparticles, have been investigated for use in drug delivery systems, regenerative medicine, and scaffolds for tissue engineering. Some of the most attractive nanoparticles for biomedical applications are nanoclays. According to their mineralogical composition, approximately 30 different nanoclays exist, and the more commonly used clays are bentonite, halloysite, kaolinite, laponite, and montmorillonite. For millennia, clay minerals have been extensively investigated for use in antidiarrhea solutions, anti-inflammatory agents, blood purification, reducing infections, and healing of stomach ulcers. This widespread use is due to their high porosity, surface properties, large surface area, excellent biocompatibility, the potential for sustained drug release, thermal and chemical stability. We begin this review by discussing the major nanoclay types and their application in biomedicine, focusing on current research areas for halloysite in biomedicine. Finally, recent trends and future directions in HNT research for biomedical application are explored. |
| first_indexed | 2024-03-10T03:50:56Z |
| format | Article |
| id | doaj.art-186c8b8e2ad846629a2d7f96e7595030 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T03:50:56Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-186c8b8e2ad846629a2d7f96e75950302023-11-23T11:07:28ZengMDPI AGApplied Sciences2076-34172021-12-011218710.3390/app12010087Therapeutic Applications of HalloysiteMohammadmahdi Mobaraki0Sonali Karnik1Yue Li2David K. Mills3Biomaterials Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran 15916-34311, IranDepartment of Mechanical and Energy Engineering, IUPUI, Indianapolis, IN 46202, USACenter for Biomedical Engineering & Rehabilitation Science, Louisiana Tech University, Ruston, LA 71272, USACenter for Biomedical Engineering & Rehabilitation Science, Louisiana Tech University, Ruston, LA 71272, USAIn recent years, nanomaterials have attracted significant research interest for applications in biomedicine. Many kinds of engineered nanomaterials, such as lipid nanoparticles, polymeric nanoparticles, porous nanomaterials, silica, and clay nanoparticles, have been investigated for use in drug delivery systems, regenerative medicine, and scaffolds for tissue engineering. Some of the most attractive nanoparticles for biomedical applications are nanoclays. According to their mineralogical composition, approximately 30 different nanoclays exist, and the more commonly used clays are bentonite, halloysite, kaolinite, laponite, and montmorillonite. For millennia, clay minerals have been extensively investigated for use in antidiarrhea solutions, anti-inflammatory agents, blood purification, reducing infections, and healing of stomach ulcers. This widespread use is due to their high porosity, surface properties, large surface area, excellent biocompatibility, the potential for sustained drug release, thermal and chemical stability. We begin this review by discussing the major nanoclay types and their application in biomedicine, focusing on current research areas for halloysite in biomedicine. Finally, recent trends and future directions in HNT research for biomedical application are explored.https://www.mdpi.com/2076-3417/12/1/87drug deliveryhalloysitenanoclayregenerative medicinetissue engineeringwound healing |
| spellingShingle | Mohammadmahdi Mobaraki Sonali Karnik Yue Li David K. Mills Therapeutic Applications of Halloysite Applied Sciences drug delivery halloysite nanoclay regenerative medicine tissue engineering wound healing |
| title | Therapeutic Applications of Halloysite |
| title_full | Therapeutic Applications of Halloysite |
| title_fullStr | Therapeutic Applications of Halloysite |
| title_full_unstemmed | Therapeutic Applications of Halloysite |
| title_short | Therapeutic Applications of Halloysite |
| title_sort | therapeutic applications of halloysite |
| topic | drug delivery halloysite nanoclay regenerative medicine tissue engineering wound healing |
| url | https://www.mdpi.com/2076-3417/12/1/87 |
| work_keys_str_mv | AT mohammadmahdimobaraki therapeuticapplicationsofhalloysite AT sonalikarnik therapeuticapplicationsofhalloysite AT yueli therapeuticapplicationsofhalloysite AT davidkmills therapeuticapplicationsofhalloysite |