Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province, Eastern China
Background: COVID-19 has spread worldwide and become a pandemic. We report the epidemiological and clinical characteristics of cluster infections. Methods: Data of clustered cases were retrieved from the public health emergency monitoring information system of China. We analyzed the incubation perio...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221003763 |
| _version_ | 1818284398420688896 |
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| author | Jiabing Wu Xiuzhi Chen Lei Gong Shaohu Huo Xuehuan Gao Shuang Nie Fang Chen Sai Hou Dandan Song Wanwan Ma Xuqin Jiang Zhirong Liu |
| author_facet | Jiabing Wu Xiuzhi Chen Lei Gong Shaohu Huo Xuehuan Gao Shuang Nie Fang Chen Sai Hou Dandan Song Wanwan Ma Xuqin Jiang Zhirong Liu |
| author_sort | Jiabing Wu |
| collection | DOAJ |
| description | Background: COVID-19 has spread worldwide and become a pandemic. We report the epidemiological and clinical characteristics of cluster infections. Methods: Data of clustered cases were retrieved from the public health emergency monitoring information system of China. We analyzed the incubation period, generation gap, secondary attack rate, and viral load in various grouped cases. Results: A total of 60 COVID-19 infection clusters including 226 patients and 19 asymptomatic cases involving four generations were analyzed. With the increase of transmission generations, secondary attack rate decreased (P＜0.001) and severity alleviated (P = 0.008). The median incubation period and intergenerational interval were 9 and 6 days, respectively. The secondary attack rate was 7.1% in the index cases, 5.0% in the first generation, 1.0% in the second generation, and 4.7% overall. Severe cases were seen more in the index (13, 65%) and first generation (7, 35%) ones, who had a significantly higher viral load than the mild and moderate ones. Conclusions: With the increase of transmission generation, secondary infection rate and severity decreased. Severe patients had a higher virus load. Patients in the incubation period and asymptomatic carriers were potential infection sources who might play an important role in transmission. |
| first_indexed | 2024-12-13T00:52:10Z |
| format | Article |
| id | doaj.art-186efff259024635bbae45ea7893f6b8 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-13T00:52:10Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-186efff259024635bbae45ea7893f6b82022-12-22T00:04:54ZengElsevierInternational Journal of Infectious Diseases1201-97122022-04-01117372377Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province, Eastern ChinaJiabing Wu0Xiuzhi Chen1Lei Gong2Shaohu Huo3Xuehuan Gao4Shuang Nie5Fang Chen6Sai Hou7Dandan Song8Wanwan Ma9Xuqin Jiang10Zhirong Liu11Anhui Provincial Center for Disease Control and Prevention, Hefei, ChinaAnhui Provincial Center for Disease Control and Prevention, Hefei, ChinaAnhui Provincial Center for Disease Control and Prevention, Hefei, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaAnhui Provincial Center for Disease Control and Prevention, Hefei, ChinaAnhui Provincial Center for Disease Control and Prevention, Hefei, ChinaAnhui Provincial Center for Disease Control and Prevention, Hefei, ChinaAnhui Provincial Center for Disease Control and Prevention, Hefei, ChinaAnhui Provincial Center for Disease Control and Prevention, Hefei, ChinaAnhui Provincial Center for Disease Control and Prevention, Hefei, ChinaDepartment of Respiratory Medicine, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Correspondence author at: Anhui Provincial Center for Disease Control and Prevention, No.12560, Fanhua Avenue, Hefei, Anhui, 230601, China.Anhui Provincial Center for Disease Control and Prevention, Hefei, China; Correspondence author at: Anhui Provincial Center for Disease Control and Prevention, No.12560, Fanhua Avenue, Hefei, Anhui, 230601, China.Background: COVID-19 has spread worldwide and become a pandemic. We report the epidemiological and clinical characteristics of cluster infections. Methods: Data of clustered cases were retrieved from the public health emergency monitoring information system of China. We analyzed the incubation period, generation gap, secondary attack rate, and viral load in various grouped cases. Results: A total of 60 COVID-19 infection clusters including 226 patients and 19 asymptomatic cases involving four generations were analyzed. With the increase of transmission generations, secondary attack rate decreased (P＜0.001) and severity alleviated (P = 0.008). The median incubation period and intergenerational interval were 9 and 6 days, respectively. The secondary attack rate was 7.1% in the index cases, 5.0% in the first generation, 1.0% in the second generation, and 4.7% overall. Severe cases were seen more in the index (13, 65%) and first generation (7, 35%) ones, who had a significantly higher viral load than the mild and moderate ones. Conclusions: With the increase of transmission generation, secondary infection rate and severity decreased. Severe patients had a higher virus load. Patients in the incubation period and asymptomatic carriers were potential infection sources who might play an important role in transmission.http://www.sciencedirect.com/science/article/pii/S1201971221003763Coronavirus disease 19SARS-CoV-2FeaturesCluster infectionIncubation periodTransmission |
| spellingShingle | Jiabing Wu Xiuzhi Chen Lei Gong Shaohu Huo Xuehuan Gao Shuang Nie Fang Chen Sai Hou Dandan Song Wanwan Ma Xuqin Jiang Zhirong Liu Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province, Eastern China International Journal of Infectious Diseases Coronavirus disease 19 SARS-CoV-2 Features Cluster infection Incubation period Transmission |
| title | Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province, Eastern China |
| title_full | Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province, Eastern China |
| title_fullStr | Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province, Eastern China |
| title_full_unstemmed | Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province, Eastern China |
| title_short | Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province, Eastern China |
| title_sort | epidemiological and clinical features of sars cov 2 cluster infection in anhui province eastern china |
| topic | Coronavirus disease 19 SARS-CoV-2 Features Cluster infection Incubation period Transmission |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221003763 |
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