Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy
Metal-organic frameworks (MOFs), with biocompatible and bio-friendly properties, exhibit intriguing potential for the drug delivery system and imaging-guided synergistic cancer theranostics. Even though tremendous attention has been attracted on MOFs-based therapeutics, which play a crucial role in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1361347/full |
| _version_ | 1797337858837577728 |
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| author | Chen Wang Chen Wang Shufang Ning Jinling Mai Shanyu Zhao Wenwei Jiang Junjie Pan Feifei Wu Qiuju Liu Qinle Zhang |
| author_facet | Chen Wang Chen Wang Shufang Ning Jinling Mai Shanyu Zhao Wenwei Jiang Junjie Pan Feifei Wu Qiuju Liu Qinle Zhang |
| author_sort | Chen Wang |
| collection | DOAJ |
| description | Metal-organic frameworks (MOFs), with biocompatible and bio-friendly properties, exhibit intriguing potential for the drug delivery system and imaging-guided synergistic cancer theranostics. Even though tremendous attention has been attracted on MOFs-based therapeutics, which play a crucial role in therapeutic drugs, gene, and biomedical agents delivery of cancer therapy, they are often explored as simple nanocarriers without further “intelligent” functions. Herein, Fe-doped MOFs with CoP nanoparticles loading were rationally designed and synthesized for photothermal enhanced reactive oxygen species (ROS)-mediated treatment. Fe-ZIFs@CoP could generate efficient ROS through the Fenton reaction while depleting glutathione for amplifying oxidative stress. Particularly, due to the photothermal effect of Fe-ZIFs@CoP, the hyperthermia generated by as-synthesized Fe-ZIFs@CoP facilitated the advanced performance of the Fenton effect for a high amount of ROS generation. The promising “all-in-one” synergistic MOFs platform herein reported provides some prospects for future directions in this area. |
| first_indexed | 2024-03-08T09:22:41Z |
| format | Article |
| id | doaj.art-18706b2c595e4930988bdf61ebd1c586 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T09:22:41Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-18706b2c595e4930988bdf61ebd1c5862024-01-31T11:03:13ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-01-011210.3389/fbioe.2024.13613471361347Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapyChen Wang0Chen Wang1Shufang Ning2Jinling Mai3Shanyu Zhao4Wenwei Jiang5Junjie Pan6Feifei Wu7Qiuju Liu8Qinle Zhang9Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaGuangxi Medical University Cancer Hospital, Nanning, ChinaGuangxi Medical University Cancer Hospital, Nanning, ChinaThe First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaGuangxi Medical University Cancer Hospital, Nanning, ChinaGuangxi Medical University Cancer Hospital, Nanning, ChinaGuangxi Medical University Cancer Hospital, Nanning, ChinaGuangxi Medical University Cancer Hospital, Nanning, ChinaGuangxi Medical University Cancer Hospital, Nanning, ChinaMaternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaMetal-organic frameworks (MOFs), with biocompatible and bio-friendly properties, exhibit intriguing potential for the drug delivery system and imaging-guided synergistic cancer theranostics. Even though tremendous attention has been attracted on MOFs-based therapeutics, which play a crucial role in therapeutic drugs, gene, and biomedical agents delivery of cancer therapy, they are often explored as simple nanocarriers without further “intelligent” functions. Herein, Fe-doped MOFs with CoP nanoparticles loading were rationally designed and synthesized for photothermal enhanced reactive oxygen species (ROS)-mediated treatment. Fe-ZIFs@CoP could generate efficient ROS through the Fenton reaction while depleting glutathione for amplifying oxidative stress. Particularly, due to the photothermal effect of Fe-ZIFs@CoP, the hyperthermia generated by as-synthesized Fe-ZIFs@CoP facilitated the advanced performance of the Fenton effect for a high amount of ROS generation. The promising “all-in-one” synergistic MOFs platform herein reported provides some prospects for future directions in this area.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1361347/fullFe-based MOFsROSCoPFenton reactionphotothermal effect |
| spellingShingle | Chen Wang Chen Wang Shufang Ning Jinling Mai Shanyu Zhao Wenwei Jiang Junjie Pan Feifei Wu Qiuju Liu Qinle Zhang Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy Frontiers in Bioengineering and Biotechnology Fe-based MOFs ROS CoP Fenton reaction photothermal effect |
| title | Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy |
| title_full | Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy |
| title_fullStr | Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy |
| title_full_unstemmed | Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy |
| title_short | Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy |
| title_sort | rational designed fe zifs cop nanoplatforms for photothermal enhanced ros mediated tumor therapy |
| topic | Fe-based MOFs ROS CoP Fenton reaction photothermal effect |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1361347/full |
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