The role of p53 in the alternation of vascular functions
Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system. During the aging process, normal functions of vascular cells and tissue progressively lost and eventually develop vascular diseases. Endotheli...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.981152/full |
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| author | Gabriel Hoi-Huen Chan Enoch Chan Carsten Tsun-Ka Kwok George Pak-Heng Leung Simon Ming-Yuen Lee Sai-Wang Seto Sai-Wang Seto Sai-Wang Seto |
| author_facet | Gabriel Hoi-Huen Chan Enoch Chan Carsten Tsun-Ka Kwok George Pak-Heng Leung Simon Ming-Yuen Lee Sai-Wang Seto Sai-Wang Seto Sai-Wang Seto |
| author_sort | Gabriel Hoi-Huen Chan |
| collection | DOAJ |
| description | Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system. During the aging process, normal functions of vascular cells and tissue progressively lost and eventually develop vascular diseases. Endothelial dysfunction, reduced bioavailability of endothelium-derived nitric oxide are usual phenomena observed in patients with cardiovascular diseases. Myriad of studies have been done to investigate to delay the vascular dysfunction or improve the vascular function to prolong the aging process. Tumor suppressor gene p53, also a transcription factor, act as a gatekeeper to regulate a number of genes to maintain normal cell function including but not limited to cell proliferation, cell apoptosis. p53 also crosstalk with other key transcription factors like hypoxia-inducible factor 1 alpha that contribute to the progression of cardiovascular diseases. Therefore, in recent three decades, p53 has drawn scientists’ attention on its effects in vascular function. Though the role of tumor suppressor gene p53 is still not clear in vascular function, it is found to play regulatory roles and may involve in vascular remodeling, atherosclerosis or pulmonary hypertension. p53 may have a divergent role in endothelial and vascular muscle cells in those conditions. In this review, we describe the different effects of p53 in cardiovascular physiology. Further studies on the effects of endothelial cell-specific p53 deficiency on atherosclerotic plaque formation in common animal models are required before the therapeutic potential can be realized. |
| first_indexed | 2024-04-12T05:05:41Z |
| format | Article |
| id | doaj.art-1870e783e08d4239968713a32f9c7980 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T05:05:41Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-1870e783e08d4239968713a32f9c79802022-12-22T03:46:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.981152981152The role of p53 in the alternation of vascular functionsGabriel Hoi-Huen Chan0Enoch Chan1Carsten Tsun-Ka Kwok2George Pak-Heng Leung3Simon Ming-Yuen Lee4Sai-Wang Seto5Sai-Wang Seto6Sai-Wang Seto7Division of Science, Engineering and Health Studies, College of Professional and Continuing Education, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaSchool of Clinical Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, ChinaDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaDepartment of Pharmacology and Pharmacy, The University of Hong Kong, Kowloon, Hong Kong SAR, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, ChinaDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaResearch Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaNICM Health Research Institute, Western Sydney University, Penrith, NSW, AustraliaAgeing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system. During the aging process, normal functions of vascular cells and tissue progressively lost and eventually develop vascular diseases. Endothelial dysfunction, reduced bioavailability of endothelium-derived nitric oxide are usual phenomena observed in patients with cardiovascular diseases. Myriad of studies have been done to investigate to delay the vascular dysfunction or improve the vascular function to prolong the aging process. Tumor suppressor gene p53, also a transcription factor, act as a gatekeeper to regulate a number of genes to maintain normal cell function including but not limited to cell proliferation, cell apoptosis. p53 also crosstalk with other key transcription factors like hypoxia-inducible factor 1 alpha that contribute to the progression of cardiovascular diseases. Therefore, in recent three decades, p53 has drawn scientists’ attention on its effects in vascular function. Though the role of tumor suppressor gene p53 is still not clear in vascular function, it is found to play regulatory roles and may involve in vascular remodeling, atherosclerosis or pulmonary hypertension. p53 may have a divergent role in endothelial and vascular muscle cells in those conditions. In this review, we describe the different effects of p53 in cardiovascular physiology. Further studies on the effects of endothelial cell-specific p53 deficiency on atherosclerotic plaque formation in common animal models are required before the therapeutic potential can be realized.https://www.frontiersin.org/articles/10.3389/fphar.2022.981152/fullatherosclerosisp53vascular smooth muscle cellendothelial dysfunctionvascular smooth muscle proliferationvascular smooth muscle migration |
| spellingShingle | Gabriel Hoi-Huen Chan Enoch Chan Carsten Tsun-Ka Kwok George Pak-Heng Leung Simon Ming-Yuen Lee Sai-Wang Seto Sai-Wang Seto Sai-Wang Seto The role of p53 in the alternation of vascular functions Frontiers in Pharmacology atherosclerosis p53 vascular smooth muscle cell endothelial dysfunction vascular smooth muscle proliferation vascular smooth muscle migration |
| title | The role of p53 in the alternation of vascular functions |
| title_full | The role of p53 in the alternation of vascular functions |
| title_fullStr | The role of p53 in the alternation of vascular functions |
| title_full_unstemmed | The role of p53 in the alternation of vascular functions |
| title_short | The role of p53 in the alternation of vascular functions |
| title_sort | role of p53 in the alternation of vascular functions |
| topic | atherosclerosis p53 vascular smooth muscle cell endothelial dysfunction vascular smooth muscle proliferation vascular smooth muscle migration |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.981152/full |
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