Dexmedetomidine Attenuates Lipopolysaccharide-Induced Sympathetic Activation and Sepsis via Suppressing Superoxide Signaling in Paraventricular Nucleus

Dexmedetomidine Attenuates Lipopolysaccharide-Induced Sympathetic Activation and Sepsis via Suppressing Superoxide Signaling in Paraventricular Nucleus

Sympathetic overactivity contributes to the pathogenesis of sepsis. The selective α2-adrenergic receptor agonist dexmedetomidine (DEX) is widely used for perioperative sedation and analgesia. We aimed to determine the central roles and mechanisms of DEX in attenuating sympathetic activity and inflam...

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Bibliographic Details
Main Authors: Jin-Hua Bo, Jing-Xiao Wang, Xiao-Li Wang, Yang Jiao, Ming Jiang, Jun-Liu Chen, Wen-Yuan Hao, Qi Chen, Yue-Hua Li, Zheng-Liang Ma, Guo-Qing Zhu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antioxidants
Subjects:
dexmedetomidine
sepsis
sympathetic activity
paraventricular nucleus
inflammation
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/11/12/2395

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