Overview of cellular homeostasis-associated nuclear envelope lamins and associated input signals
With the discovery of the role of the nuclear envelope protein lamin in human genetic diseases, further diverse roles of lamins have been elucidated. The roles of lamins have been addressed in cellular homeostasis including gene regulation, cell cycle, cellular senescence, adipogenesis, bone remodel...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1173514/full |
| _version_ | 1797828982113042432 |
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| author | Hyeong Jae Kim Peter C. W. Lee Jeong Hee Hong |
| author_facet | Hyeong Jae Kim Peter C. W. Lee Jeong Hee Hong |
| author_sort | Hyeong Jae Kim |
| collection | DOAJ |
| description | With the discovery of the role of the nuclear envelope protein lamin in human genetic diseases, further diverse roles of lamins have been elucidated. The roles of lamins have been addressed in cellular homeostasis including gene regulation, cell cycle, cellular senescence, adipogenesis, bone remodeling as well as modulation of cancer biology. Features of laminopathies line with oxidative stress-associated cellular senescence, differentiation, and longevity and share with downstream of aging-oxidative stress. Thus, in this review, we highlighted various roles of lamin as key molecule of nuclear maintenance, specially lamin-A/C, and mutated LMNA gene clearly reveal aging-related genetic phenotypes, such as enhanced differentiation, adipogenesis, and osteoporosis. The modulatory roles of lamin-A/C in stem cell differentiation, skin, cardiac regulation, and oncology have also been elucidated. In addition to recent advances in laminopathies, we highlighted for the first kinase-dependent nuclear lamin biology and recently developed modulatory mechanisms or effector signals of lamin regulation. Advanced knowledge of the lamin-A/C proteins as diverse signaling modulators might be biological key to unlocking the complex signaling of aging-related human diseases and homeostasis in cellular process. |
| first_indexed | 2024-04-09T13:14:12Z |
| format | Article |
| id | doaj.art-1873861d4cbd494eb3a9a273b184d02c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-09T13:14:12Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-1873861d4cbd494eb3a9a273b184d02c2023-05-12T04:47:30ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-05-011110.3389/fcell.2023.11735141173514Overview of cellular homeostasis-associated nuclear envelope lamins and associated input signalsHyeong Jae Kim0Peter C. W. Lee1Jeong Hee Hong2Department of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of KoreaLung Cancer Research Center, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of KoreaDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of KoreaWith the discovery of the role of the nuclear envelope protein lamin in human genetic diseases, further diverse roles of lamins have been elucidated. The roles of lamins have been addressed in cellular homeostasis including gene regulation, cell cycle, cellular senescence, adipogenesis, bone remodeling as well as modulation of cancer biology. Features of laminopathies line with oxidative stress-associated cellular senescence, differentiation, and longevity and share with downstream of aging-oxidative stress. Thus, in this review, we highlighted various roles of lamin as key molecule of nuclear maintenance, specially lamin-A/C, and mutated LMNA gene clearly reveal aging-related genetic phenotypes, such as enhanced differentiation, adipogenesis, and osteoporosis. The modulatory roles of lamin-A/C in stem cell differentiation, skin, cardiac regulation, and oncology have also been elucidated. In addition to recent advances in laminopathies, we highlighted for the first kinase-dependent nuclear lamin biology and recently developed modulatory mechanisms or effector signals of lamin regulation. Advanced knowledge of the lamin-A/C proteins as diverse signaling modulators might be biological key to unlocking the complex signaling of aging-related human diseases and homeostasis in cellular process.https://www.frontiersin.org/articles/10.3389/fcell.2023.1173514/fulllaminnuclear envelopescenescenceredox hemostasiscell cycle |
| spellingShingle | Hyeong Jae Kim Peter C. W. Lee Jeong Hee Hong Overview of cellular homeostasis-associated nuclear envelope lamins and associated input signals Frontiers in Cell and Developmental Biology lamin nuclear envelope scenescence redox hemostasis cell cycle |
| title | Overview of cellular homeostasis-associated nuclear envelope lamins and associated input signals |
| title_full | Overview of cellular homeostasis-associated nuclear envelope lamins and associated input signals |
| title_fullStr | Overview of cellular homeostasis-associated nuclear envelope lamins and associated input signals |
| title_full_unstemmed | Overview of cellular homeostasis-associated nuclear envelope lamins and associated input signals |
| title_short | Overview of cellular homeostasis-associated nuclear envelope lamins and associated input signals |
| title_sort | overview of cellular homeostasis associated nuclear envelope lamins and associated input signals |
| topic | lamin nuclear envelope scenescence redox hemostasis cell cycle |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1173514/full |
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