Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case series
Although Candida species are common pathogens for nosocomial infections, Candida endocarditis is still considered a rare entity. Here, we report two cases of Candida parapsilosis endovascular infections in patients with prosthetic valves, both of which responded to combination antifungal therapy wit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-01-01
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| Series: | IDCases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250919300241 |
| _version_ | 1819156915424329728 |
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| author | Tania Ahuja Karen Fong Eddie Louie |
| author_facet | Tania Ahuja Karen Fong Eddie Louie |
| author_sort | Tania Ahuja |
| collection | DOAJ |
| description | Although Candida species are common pathogens for nosocomial infections, Candida endocarditis is still considered a rare entity. Here, we report two cases of Candida parapsilosis endovascular infections in patients with prosthetic valves, both of which responded to combination antifungal therapy without surgical intervention. Additionally, T2 magnetic resonance (T2MR) was used to assess for resolution of invasive candidiasis. The first case is of an elderly man with Candida parapsilosis endovascular infection who responded to combination antifungal therapy with micafungin and fluconazole followed by suppressive therapy, without surgical intervention. The second case is of a middle-aged man with Candida parapsilosis prosthetic valve endocarditis who also responded to combination antifungal therapy with micafungin, flucytosine and fluconazole, without surgical intervention. Keywords: Endovascular infection, Candida parapsilosis, Fluconazole, Micafungin, Echinocandin, Antifungal |
| first_indexed | 2024-12-22T16:00:27Z |
| format | Article |
| id | doaj.art-187403068c73452e96f5a693d74e97f7 |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-12-22T16:00:27Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-187403068c73452e96f5a693d74e97f72022-12-21T18:20:42ZengElsevierIDCases2214-25092019-01-0115Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case seriesTania Ahuja0Karen Fong1Eddie Louie2New York University Langone Health, Department of Pharmacy, 550 First Avenue, New York, NY 10016, United States; Corresponding author.University of Maryland St. Joseph Medical Center, Department of Pharmacy, 7601 Osler Dr, Towson, MD 21204, United StatesNew York University Langone Health, Department of Medicine, Division of Infectious Diseases, 550 First Avenue, New York, NY 10016, United StatesAlthough Candida species are common pathogens for nosocomial infections, Candida endocarditis is still considered a rare entity. Here, we report two cases of Candida parapsilosis endovascular infections in patients with prosthetic valves, both of which responded to combination antifungal therapy without surgical intervention. Additionally, T2 magnetic resonance (T2MR) was used to assess for resolution of invasive candidiasis. The first case is of an elderly man with Candida parapsilosis endovascular infection who responded to combination antifungal therapy with micafungin and fluconazole followed by suppressive therapy, without surgical intervention. The second case is of a middle-aged man with Candida parapsilosis prosthetic valve endocarditis who also responded to combination antifungal therapy with micafungin, flucytosine and fluconazole, without surgical intervention. Keywords: Endovascular infection, Candida parapsilosis, Fluconazole, Micafungin, Echinocandin, Antifungalhttp://www.sciencedirect.com/science/article/pii/S2214250919300241 |
| spellingShingle | Tania Ahuja Karen Fong Eddie Louie Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case series IDCases |
| title | Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case series |
| title_full | Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case series |
| title_fullStr | Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case series |
| title_full_unstemmed | Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case series |
| title_short | Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case series |
| title_sort | combination antifungal therapy for treatment of candida parapsilosis prosthetic valve endocarditis and utility of t2candida panel r a case series |
| url | http://www.sciencedirect.com/science/article/pii/S2214250919300241 |
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