The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity

The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity

Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting factors, BosR and Rrp2. Activation of this pathway occurs within ticks during the nymphal blood meal when RpoS, the eff...

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Bibliographic Details
Main Authors: Melissa J. Caimano, Ashley M. Groshong, Alexia Belperron, Jialing Mao, Kelly L. Hawley, Amit Luthra, Danielle E. Graham, Christopher G. Earnhart, Richard T. Marconi, Linda K. Bockenstedt, Jon S. Blevins, Justin D. Radolf
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Microbiology
Subjects:
Borrelia burgdorferi
Lyme disease
rpoS
persistence
gene regulation
vector borne disease
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01923/full

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