Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
Abstract Epilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-08-01
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| Series: | Epilepsia Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/epi4.12567 |
| _version_ | 1818492286202281984 |
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| author | Lorena Bonilla Gerard Esteruelas Miren Ettcheto Marta Espina María Luisa García Antoni Camins Eliana B. Souto Amanda Cano Elena Sánchez‐López |
| author_facet | Lorena Bonilla Gerard Esteruelas Miren Ettcheto Marta Espina María Luisa García Antoni Camins Eliana B. Souto Amanda Cano Elena Sánchez‐López |
| author_sort | Lorena Bonilla |
| collection | DOAJ |
| description | Abstract Epilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments and present refractory epilepsy. In this context, nanomedicine constitutes a promising alternative to enhance the central nervous system bioavailability of antiseizure medications. The encapsulation of different chemical compounds at once in a variety of controlled drug delivery systems gives rise to an enhanced drug effectiveness mainly due to their targeting and penetration into the deepest brain region and the protection of the drug chemical structure. Thus, in this review we will explore the recent advances in the development of drugs associated with polymeric and lipid‐based nanocarriers as novel tools for the management of epilepsy disorders. |
| first_indexed | 2024-12-10T17:41:02Z |
| format | Article |
| id | doaj.art-18745382e2204d729190d00184112fa0 |
| institution | Directory Open Access Journal |
| issn | 2470-9239 |
| language | English |
| last_indexed | 2024-12-10T17:41:02Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Epilepsia Open |
| spelling | doaj.art-18745382e2204d729190d00184112fa02022-12-22T01:39:22ZengWileyEpilepsia Open2470-92392022-08-017S1S121S13210.1002/epi4.12567Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challengesLorena Bonilla0Gerard Esteruelas1Miren Ettcheto2Marta Espina3María Luisa García4Antoni Camins5Eliana B. Souto6Amanda Cano7Elena Sánchez‐López8Department of Pharmacy Pharmaceutical Technology and Physical Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona Barcelona SpainDepartment of Pharmacy Pharmaceutical Technology and Physical Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona Barcelona SpainCentre for Biomedical Research in Neurodegenerative Diseases Network (CIBERNED) Carlos III Health Institute Madrid SpainDepartment of Pharmacy Pharmaceutical Technology and Physical Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona Barcelona SpainDepartment of Pharmacy Pharmaceutical Technology and Physical Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona Barcelona SpainCentre for Biomedical Research in Neurodegenerative Diseases Network (CIBERNED) Carlos III Health Institute Madrid SpainDepartment of Pharmaceutical Technology Faculty of Pharmacy, University of Coimbra Coimbra PortugalDepartment of Pharmacy Pharmaceutical Technology and Physical Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona Barcelona SpainDepartment of Pharmacy Pharmaceutical Technology and Physical Chemistry Faculty of Pharmacy and Food Sciences University of Barcelona Barcelona SpainAbstract Epilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments and present refractory epilepsy. In this context, nanomedicine constitutes a promising alternative to enhance the central nervous system bioavailability of antiseizure medications. The encapsulation of different chemical compounds at once in a variety of controlled drug delivery systems gives rise to an enhanced drug effectiveness mainly due to their targeting and penetration into the deepest brain region and the protection of the drug chemical structure. Thus, in this review we will explore the recent advances in the development of drugs associated with polymeric and lipid‐based nanocarriers as novel tools for the management of epilepsy disorders.https://doi.org/10.1002/epi4.12567epilepsylipid nanoparticlesnanomedicinenanotechnologyneurodegenerative diseasespolymeric nanoparticles |
| spellingShingle | Lorena Bonilla Gerard Esteruelas Miren Ettcheto Marta Espina María Luisa García Antoni Camins Eliana B. Souto Amanda Cano Elena Sánchez‐López Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges Epilepsia Open epilepsy lipid nanoparticles nanomedicine nanotechnology neurodegenerative diseases polymeric nanoparticles |
| title | Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
| title_full | Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
| title_fullStr | Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
| title_full_unstemmed | Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
| title_short | Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
| title_sort | biodegradable nanoparticles for the treatment of epilepsy from current advances to future challenges |
| topic | epilepsy lipid nanoparticles nanomedicine nanotechnology neurodegenerative diseases polymeric nanoparticles |
| url | https://doi.org/10.1002/epi4.12567 |
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