The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study
Coronavirus disease 2019 (COVID-19) is frequently associated with iron dyshomeostasis. The latter is related to acute disease severity and COVID-19 convalescence. We herein describe iron dyshomeostasis at COVID-19 follow-up and its association with long-term pulmonary and symptomatic recovery. The p...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/12/6/546 |
| _version_ | 1827658505548464128 |
|---|---|
| author | Thomas Sonnweber Philipp Grubwieser Sabina Sahanic Anna Katharina Böhm Alex Pizzini Anna Luger Christoph Schwabl Sabine Koppelstätter Katharina Kurz Bernhard Puchner Barbara Sperner-Unterweger Katharina Hüfner Ewald Wöll Manfred Nairz Gerlig Widmann Ivan Tancevski Judith Löffler-Ragg Günter Weiss |
| author_facet | Thomas Sonnweber Philipp Grubwieser Sabina Sahanic Anna Katharina Böhm Alex Pizzini Anna Luger Christoph Schwabl Sabine Koppelstätter Katharina Kurz Bernhard Puchner Barbara Sperner-Unterweger Katharina Hüfner Ewald Wöll Manfred Nairz Gerlig Widmann Ivan Tancevski Judith Löffler-Ragg Günter Weiss |
| author_sort | Thomas Sonnweber |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) is frequently associated with iron dyshomeostasis. The latter is related to acute disease severity and COVID-19 convalescence. We herein describe iron dyshomeostasis at COVID-19 follow-up and its association with long-term pulmonary and symptomatic recovery. The prospective, multicentre, observational cohort study “Development of Interstitial Lung Disease (ILD) in Patients With Severe SARS-CoV-2 Infection (CovILD)” encompasses serial extensive clinical, laboratory, functional and imaging evaluations at 60, 100, 180 and 360 days after COVID-19 onset. We included 108 individuals with mild-to-critical acute COVID-19, whereas 75% presented with severe acute disease. At 60 days post-COVID-19 follow-up, hyperferritinaemia (35% of patients), iron deficiency (24% of the cohort) and anaemia (9% of the patients) were frequently found. Anaemia of inflammation (AI) was the predominant feature at early post-acute follow-up, whereas the anaemia phenotype shifted towards iron deficiency anaemia (IDA) and combinations of IDA and AI until the 360 days follow-up. The prevalence of anaemia significantly decreased over time, but iron dyshomeostasis remained a frequent finding throughout the study. Neither iron dyshomeostasis nor anaemia were related to persisting structural lung impairment, but both were associated with impaired stress resilience at long-term COVID-19 follow-up. To conclude, iron dyshomeostasis and anaemia are frequent findings after COVID-19 and may contribute to its long-term symptomatic outcome. |
| first_indexed | 2024-03-09T23:03:39Z |
| format | Article |
| id | doaj.art-1874c1e7bbb741988111f7ad9b024246 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T23:03:39Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-1874c1e7bbb741988111f7ad9b0242462023-11-23T17:56:27ZengMDPI AGMetabolites2218-19892022-06-0112654610.3390/metabo12060546The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort StudyThomas Sonnweber0Philipp Grubwieser1Sabina Sahanic2Anna Katharina Böhm3Alex Pizzini4Anna Luger5Christoph Schwabl6Sabine Koppelstätter7Katharina Kurz8Bernhard Puchner9Barbara Sperner-Unterweger10Katharina Hüfner11Ewald Wöll12Manfred Nairz13Gerlig Widmann14Ivan Tancevski15Judith Löffler-Ragg16Günter Weiss17Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Radiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Radiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, University Clinic for Psychiatry II, 6020 Innsbruck, AustriaDepartment of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, University Clinic for Psychiatry II, 6020 Innsbruck, AustriaDepartment of Internal Medicine, St. Vinzenz Hospital, 6511 Zams, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Radiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, AustriaCoronavirus disease 2019 (COVID-19) is frequently associated with iron dyshomeostasis. The latter is related to acute disease severity and COVID-19 convalescence. We herein describe iron dyshomeostasis at COVID-19 follow-up and its association with long-term pulmonary and symptomatic recovery. The prospective, multicentre, observational cohort study “Development of Interstitial Lung Disease (ILD) in Patients With Severe SARS-CoV-2 Infection (CovILD)” encompasses serial extensive clinical, laboratory, functional and imaging evaluations at 60, 100, 180 and 360 days after COVID-19 onset. We included 108 individuals with mild-to-critical acute COVID-19, whereas 75% presented with severe acute disease. At 60 days post-COVID-19 follow-up, hyperferritinaemia (35% of patients), iron deficiency (24% of the cohort) and anaemia (9% of the patients) were frequently found. Anaemia of inflammation (AI) was the predominant feature at early post-acute follow-up, whereas the anaemia phenotype shifted towards iron deficiency anaemia (IDA) and combinations of IDA and AI until the 360 days follow-up. The prevalence of anaemia significantly decreased over time, but iron dyshomeostasis remained a frequent finding throughout the study. Neither iron dyshomeostasis nor anaemia were related to persisting structural lung impairment, but both were associated with impaired stress resilience at long-term COVID-19 follow-up. To conclude, iron dyshomeostasis and anaemia are frequent findings after COVID-19 and may contribute to its long-term symptomatic outcome.https://www.mdpi.com/2218-1989/12/6/546COVID-19SARS-CoV-2inflammationiron metabolismhyperferritinaemiahepcidin |
| spellingShingle | Thomas Sonnweber Philipp Grubwieser Sabina Sahanic Anna Katharina Böhm Alex Pizzini Anna Luger Christoph Schwabl Sabine Koppelstätter Katharina Kurz Bernhard Puchner Barbara Sperner-Unterweger Katharina Hüfner Ewald Wöll Manfred Nairz Gerlig Widmann Ivan Tancevski Judith Löffler-Ragg Günter Weiss The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study Metabolites COVID-19 SARS-CoV-2 inflammation iron metabolism hyperferritinaemia hepcidin |
| title | The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study |
| title_full | The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study |
| title_fullStr | The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study |
| title_full_unstemmed | The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study |
| title_short | The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study |
| title_sort | impact of iron dyshomeostasis and anaemia on long term pulmonary recovery and persisting symptom burden after covid 19 a prospective observational cohort study |
| topic | COVID-19 SARS-CoV-2 inflammation iron metabolism hyperferritinaemia hepcidin |
| url | https://www.mdpi.com/2218-1989/12/6/546 |
| work_keys_str_mv | AT thomassonnweber theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT philippgrubwieser theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT sabinasahanic theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT annakatharinabohm theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT alexpizzini theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT annaluger theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT christophschwabl theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT sabinekoppelstatter theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT katharinakurz theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT bernhardpuchner theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT barbaraspernerunterweger theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT katharinahufner theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT ewaldwoll theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT manfrednairz theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT gerligwidmann theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT ivantancevski theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT judithlofflerragg theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT gunterweiss theimpactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT thomassonnweber impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT philippgrubwieser impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT sabinasahanic impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT annakatharinabohm impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT alexpizzini impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT annaluger impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT christophschwabl impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT sabinekoppelstatter impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT katharinakurz impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT bernhardpuchner impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT barbaraspernerunterweger impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT katharinahufner impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT ewaldwoll impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT manfrednairz impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT gerligwidmann impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT ivantancevski impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT judithlofflerragg impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy AT gunterweiss impactofirondyshomeostasisandanaemiaonlongtermpulmonaryrecoveryandpersistingsymptomburdenaftercovid19aprospectiveobservationalcohortstudy |