Mutant p53 Gain-of-Function Induces Migration and Invasion through Overexpression of miR-182-5p in Cancer Cells

Mutant p53 Gain-of-Function Induces Migration and Invasion through Overexpression of miR-182-5p in Cancer Cells

The master-key TP53 gene is a tumor suppressor that is mutated in more than 50% of human cancers. Some p53 mutants lose their tumor suppressor activity and acquire new oncogenic functions, known as a gain of function (GOF). Recent studies have shown that p53 mutants can exert oncogenic effects throu...

Full description

Bibliographic Details
Main Authors: Tzitzijanik Madrigal, Daniel Ortega-Bernal, Luis A. Herrera, Claudia Haydée González-De la Rosa, Guadalupe Domínguez-Gómez, Elena Aréchaga-Ocampo, José Díaz-Chávez
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
miRNAs
mutant p53
gain of function
cancer
Online Access:https://www.mdpi.com/2073-4409/12/20/2506

Similar Items

Similar Items