Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.

Ferroptosis is a form of programmed cell death associated with inflammation, neurodegeneration, and ischemia. Vitamin E (alpha-tocopherol) has been reported to prevent ferroptosis, but the mechanism by which this occurs is controversial. To elucidate the biochemical mechanism of vitamin E activity,...

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Bibliographic Details
Main Authors: Andrew Hinman, Charles R Holst, Joey C Latham, Joel J Bruegger, Gözde Ulas, Kevin P McCusker, Akiko Amagata, Dana Davis, Kevin G Hoff, Amanda H Kahn-Kirby, Virna Kim, Yuko Kosaka, Edgar Lee, Stephanie A Malone, Janet J Mei, Steve James Richards, Veronica Rivera, Guy Miller, Jeffrey K Trimmer, William D Shrader
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6093661?pdf=render

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