Microorganisms Associated with the Marine Sponge <i>Scopalina hapalia</i>: A Reservoir of Bioactive Molecules to Slow Down the Aging Process
Aging research aims at developing interventions that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to delay aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to pro...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/9/1262 |
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| author | Charifat Said Hassane Mireille Fouillaud Géraldine Le Goff Aimilia D. Sklirou Jean Bernard Boyer Ioannis P. Trougakos Moran Jerabek Jérôme Bignon Nicole J. de Voogd Jamal Ouazzani Anne Gauvin-Bialecki Laurent Dufossé |
| author_facet | Charifat Said Hassane Mireille Fouillaud Géraldine Le Goff Aimilia D. Sklirou Jean Bernard Boyer Ioannis P. Trougakos Moran Jerabek Jérôme Bignon Nicole J. de Voogd Jamal Ouazzani Anne Gauvin-Bialecki Laurent Dufossé |
| author_sort | Charifat Said Hassane |
| collection | DOAJ |
| description | Aging research aims at developing interventions that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to delay aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge <i>Scopalina hapalia</i> was investigated by metagenomic analysis. Twenty-six bacterial and two archaeal phyla were recovered from the sponge, of which the <i>Proteobacteria</i> phylum was the most abundant. In addition, thirty isolates from <i>S. hapalia</i> were selected and cultivated for identification and secondary metabolites production. The selected isolates were affiliated to the genera <i>Bacillus</i>, <i>Micromonospora</i>, <i>Rhodoccocus</i>, <i>Salinispora</i>, <i>Aspergillus</i>, <i>Chaetomium</i>, <i>Nigrospora</i> and unidentified genera related to the family <i>Thermoactinomycetaceae</i>. Crude extracts from selected microbial cultures were found to be active against seven targets i.e., elastase, tyrosinase, catalase, sirtuin 1, Cyclin-dependent kinase 7 (CDK7), Fyn kinase and proteasome. These results highlight the potential of microorganisms associated with a marine sponge from Mayotte to produce anti-aging compounds. Future work will focus on the isolation and the characterization of bioactive molecules. |
| first_indexed | 2024-03-10T17:06:32Z |
| format | Article |
| id | doaj.art-187704cfa0a042e6b97d87ae439f3b4c |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T17:06:32Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-187704cfa0a042e6b97d87ae439f3b4c2023-11-20T10:46:15ZengMDPI AGMicroorganisms2076-26072020-08-0189126210.3390/microorganisms8091262Microorganisms Associated with the Marine Sponge <i>Scopalina hapalia</i>: A Reservoir of Bioactive Molecules to Slow Down the Aging ProcessCharifat Said Hassane0Mireille Fouillaud1Géraldine Le Goff2Aimilia D. Sklirou3Jean Bernard Boyer4Ioannis P. Trougakos5Moran Jerabek6Jérôme Bignon7Nicole J. de Voogd8Jamal Ouazzani9Anne Gauvin-Bialecki10Laurent Dufossé11Laboratoire de Chimie et Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La Réunion, FranceLaboratoire de Chimie et Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La Réunion, FranceInstitut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, FranceDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, GreeceLaboratoire de Chimie et Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La Réunion, FranceDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, GreeceCrelux GmbH, Am Klopferspitz 19a, 82152 Martinsried, GermanyInstitut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, FranceNaturalis Biodiversity Center, Darwinweg 2, 2333 CR Leiden, The NetherlandsInstitut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, FranceLaboratoire de Chimie et Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La Réunion, FranceLaboratoire de Chimie et Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La Réunion, FranceAging research aims at developing interventions that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to delay aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge <i>Scopalina hapalia</i> was investigated by metagenomic analysis. Twenty-six bacterial and two archaeal phyla were recovered from the sponge, of which the <i>Proteobacteria</i> phylum was the most abundant. In addition, thirty isolates from <i>S. hapalia</i> were selected and cultivated for identification and secondary metabolites production. The selected isolates were affiliated to the genera <i>Bacillus</i>, <i>Micromonospora</i>, <i>Rhodoccocus</i>, <i>Salinispora</i>, <i>Aspergillus</i>, <i>Chaetomium</i>, <i>Nigrospora</i> and unidentified genera related to the family <i>Thermoactinomycetaceae</i>. Crude extracts from selected microbial cultures were found to be active against seven targets i.e., elastase, tyrosinase, catalase, sirtuin 1, Cyclin-dependent kinase 7 (CDK7), Fyn kinase and proteasome. These results highlight the potential of microorganisms associated with a marine sponge from Mayotte to produce anti-aging compounds. Future work will focus on the isolation and the characterization of bioactive molecules.https://www.mdpi.com/2076-2607/8/9/1262<i>Scopalina hapalia</i>Actinomycetes<i>Bacillus</i>Fungielastase inhibitiontyrosinase inhibition |
| spellingShingle | Charifat Said Hassane Mireille Fouillaud Géraldine Le Goff Aimilia D. Sklirou Jean Bernard Boyer Ioannis P. Trougakos Moran Jerabek Jérôme Bignon Nicole J. de Voogd Jamal Ouazzani Anne Gauvin-Bialecki Laurent Dufossé Microorganisms Associated with the Marine Sponge <i>Scopalina hapalia</i>: A Reservoir of Bioactive Molecules to Slow Down the Aging Process Microorganisms <i>Scopalina hapalia</i> Actinomycetes <i>Bacillus</i> Fungi elastase inhibition tyrosinase inhibition |
| title | Microorganisms Associated with the Marine Sponge <i>Scopalina hapalia</i>: A Reservoir of Bioactive Molecules to Slow Down the Aging Process |
| title_full | Microorganisms Associated with the Marine Sponge <i>Scopalina hapalia</i>: A Reservoir of Bioactive Molecules to Slow Down the Aging Process |
| title_fullStr | Microorganisms Associated with the Marine Sponge <i>Scopalina hapalia</i>: A Reservoir of Bioactive Molecules to Slow Down the Aging Process |
| title_full_unstemmed | Microorganisms Associated with the Marine Sponge <i>Scopalina hapalia</i>: A Reservoir of Bioactive Molecules to Slow Down the Aging Process |
| title_short | Microorganisms Associated with the Marine Sponge <i>Scopalina hapalia</i>: A Reservoir of Bioactive Molecules to Slow Down the Aging Process |
| title_sort | microorganisms associated with the marine sponge i scopalina hapalia i a reservoir of bioactive molecules to slow down the aging process |
| topic | <i>Scopalina hapalia</i> Actinomycetes <i>Bacillus</i> Fungi elastase inhibition tyrosinase inhibition |
| url | https://www.mdpi.com/2076-2607/8/9/1262 |
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