Adverse ocular effects of neuroleptic therapy: semiotics, pathogenesis and treatment
Antipsychotics are widely used in psychiatric practice for treating schizophrenia, bipolar disorder, and other diseases, including those treated off-label. They manifest many adverse effects, including ophthalmic ones. Some of these effects, such as persistent mydriasis, cycloplegia, extraocular mus...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2022-01-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/804 |
| _version_ | 1797878269583818752 |
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| author | A. A. Panov A. A. Petukhova Ya. V. Malygin B. D. Tsygankov M. A. Kazanfarova |
| author_facet | A. A. Panov A. A. Petukhova Ya. V. Malygin B. D. Tsygankov M. A. Kazanfarova |
| author_sort | A. A. Panov |
| collection | DOAJ |
| description | Antipsychotics are widely used in psychiatric practice for treating schizophrenia, bipolar disorder, and other diseases, including those treated off-label. They manifest many adverse effects, including ophthalmic ones. Some of these effects, such as persistent mydriasis, cycloplegia, extraocular muscle dystonia, and visual hypersensitivity attacks are reversible, since they disappear after dose reduction or drug withdrawal. Yet other side effects, such as cataracts, corneal edema, acute angle closure glaucoma and retinopathy are threatening for sight and may lead to permanent visual acuity decline and even blindness. The review provides data on the incidence of ocular side effects (both typical and atypical) of multiple antipsychotics, their clinical manifestations, pathogenesis and treatment. Eye examination is recommended for patients taking antipsychotics in the early periods of treatment and then twice a year. The psychiatrists need to know about the adverse effects of individual drugs whilst the ophthalmologists should be aware of their semiotics, pathogenesis and treatment, since timely diagnosis and treatment of pathological changes, together with antipsychotic therapy modification, prevent the development of severe and irreversible visual impairment in the majority of cases. |
| first_indexed | 2024-04-10T02:29:58Z |
| format | Article |
| id | doaj.art-187797e12f954f4eb015d352a9c03653 |
| institution | Directory Open Access Journal |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| last_indexed | 2024-04-10T02:29:58Z |
| publishDate | 2022-01-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj.art-187797e12f954f4eb015d352a9c036532023-03-13T07:54:31ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602022-01-0114417217810.21516/2072-0076-2021-14-4-172-178416Adverse ocular effects of neuroleptic therapy: semiotics, pathogenesis and treatmentA. A. Panov0A. A. Petukhova1Ya. V. Malygin2B. D. Tsygankov3M. A. Kazanfarova4ФГБОУ ВО «МГУ им. М.В. Ломоносова»ФГБОУ ВО «МГУ им. М.В. Ломоносова»ФГБОУ ВО «МГМСУ им. А.И. Евдокимова» Минздрава России; ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»ФГБОУ ВО «МГМСУ им. А.И. Евдокимова» Минздрава РоссииИЦ «Сколково»Antipsychotics are widely used in psychiatric practice for treating schizophrenia, bipolar disorder, and other diseases, including those treated off-label. They manifest many adverse effects, including ophthalmic ones. Some of these effects, such as persistent mydriasis, cycloplegia, extraocular muscle dystonia, and visual hypersensitivity attacks are reversible, since they disappear after dose reduction or drug withdrawal. Yet other side effects, such as cataracts, corneal edema, acute angle closure glaucoma and retinopathy are threatening for sight and may lead to permanent visual acuity decline and even blindness. The review provides data on the incidence of ocular side effects (both typical and atypical) of multiple antipsychotics, their clinical manifestations, pathogenesis and treatment. Eye examination is recommended for patients taking antipsychotics in the early periods of treatment and then twice a year. The psychiatrists need to know about the adverse effects of individual drugs whilst the ophthalmologists should be aware of their semiotics, pathogenesis and treatment, since timely diagnosis and treatment of pathological changes, together with antipsychotic therapy modification, prevent the development of severe and irreversible visual impairment in the majority of cases.https://roj.igb.ru/jour/article/view/804нейролептикитипичные нейролептикиатипичные нейролептикихлорпромазинкератопатияcornea verticillataкатарактапигментная ретинопатиямакулопатияретинопатия |
| spellingShingle | A. A. Panov A. A. Petukhova Ya. V. Malygin B. D. Tsygankov M. A. Kazanfarova Adverse ocular effects of neuroleptic therapy: semiotics, pathogenesis and treatment Российский офтальмологический журнал нейролептики типичные нейролептики атипичные нейролептики хлорпромазин кератопатия cornea verticillata катаракта пигментная ретинопатия макулопатия ретинопатия |
| title | Adverse ocular effects of neuroleptic therapy: semiotics, pathogenesis and treatment |
| title_full | Adverse ocular effects of neuroleptic therapy: semiotics, pathogenesis and treatment |
| title_fullStr | Adverse ocular effects of neuroleptic therapy: semiotics, pathogenesis and treatment |
| title_full_unstemmed | Adverse ocular effects of neuroleptic therapy: semiotics, pathogenesis and treatment |
| title_short | Adverse ocular effects of neuroleptic therapy: semiotics, pathogenesis and treatment |
| title_sort | adverse ocular effects of neuroleptic therapy semiotics pathogenesis and treatment |
| topic | нейролептики типичные нейролептики атипичные нейролептики хлорпромазин кератопатия cornea verticillata катаракта пигментная ретинопатия макулопатия ретинопатия |
| url | https://roj.igb.ru/jour/article/view/804 |
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