Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

Abstract Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is ind...

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Bibliographic Details
Main Authors: Sylwia Bartoszewska, Jarosław Króliczewski, David K. Crossman, Aneta Pogorzelska, Maciej Bagiński, James F. Collawn, Rafal Bartoszewski
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
XBP1s
UPR
ER stress
IRE1α
Online Access:https://doi.org/10.1186/s11658-021-00255-y

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