Skeletal muscle involvement in patients with chronic alcoholic intoxication
Chronic alcoholic myopathy (CAM) is a common manifestation of alcoholic disease; however, the pathogenesis of the former has not been fully investigated. The main mechanism for the development of CAM is postulated to be impaired protein synthesis in the muscle fibers. A comprehensive clinical, bioch...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2013-03-01
|
| Series: | Неврология, нейропсихиатрия, психосоматика |
| Subjects: | |
| Online Access: | https://nnp.ima-press.net/nnp/article/view/175 |
| _version_ | 1797876475043512320 |
|---|---|
| author | Olga Evgenyevna Zinovyeva N S Shcheglova Y V Kazantseva B S Shenkman E G Altayeva |
| author_facet | Olga Evgenyevna Zinovyeva N S Shcheglova Y V Kazantseva B S Shenkman E G Altayeva |
| author_sort | Olga Evgenyevna Zinovyeva |
| collection | DOAJ |
| description | Chronic alcoholic myopathy (CAM) is a common manifestation of alcoholic disease; however, the pathogenesis of the former has not been fully investigated. The main mechanism for the development of CAM is postulated to be impaired protein synthesis in the muscle fibers. A comprehensive clinical, biochemical, electromyographic, and morphological examination was made in 51 patients with chronic alcoholic intoxication. Morphological and morphometric studies were shown to play a determining role in the diagnosis of CAM. The clinical manifestations of skeletal muscle involvement corresponded to the magnitude of the atrophic process. Abnormalities were found in the basic components of protein synthesis at both the intracellular and systemic levels of regulation. |
| first_indexed | 2024-04-10T02:03:47Z |
| format | Article |
| id | doaj.art-18794db2774740008460aa8c673a8787 |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-04-10T02:03:47Z |
| publishDate | 2013-03-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-18794db2774740008460aa8c673a87872023-03-13T08:42:13ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422013-03-0151394210.14412/2074-2711-2013-2396175Skeletal muscle involvement in patients with chronic alcoholic intoxicationOlga Evgenyevna ZinovyevaN S ShcheglovaY V KazantsevaB S ShenkmanE G AltayevaChronic alcoholic myopathy (CAM) is a common manifestation of alcoholic disease; however, the pathogenesis of the former has not been fully investigated. The main mechanism for the development of CAM is postulated to be impaired protein synthesis in the muscle fibers. A comprehensive clinical, biochemical, electromyographic, and morphological examination was made in 51 patients with chronic alcoholic intoxication. Morphological and morphometric studies were shown to play a determining role in the diagnosis of CAM. The clinical manifestations of skeletal muscle involvement corresponded to the magnitude of the atrophic process. Abnormalities were found in the basic components of protein synthesis at both the intracellular and systemic levels of regulation.https://nnp.ima-press.net/nnp/article/view/175chronic alcoholic myopathydiagnosismuscle biopsyinsulin-growth-like growth factor 1protein synthesis |
| spellingShingle | Olga Evgenyevna Zinovyeva N S Shcheglova Y V Kazantseva B S Shenkman E G Altayeva Skeletal muscle involvement in patients with chronic alcoholic intoxication Неврология, нейропсихиатрия, психосоматика chronic alcoholic myopathy diagnosis muscle biopsy insulin-growth-like growth factor 1 protein synthesis |
| title | Skeletal muscle involvement in patients with chronic alcoholic intoxication |
| title_full | Skeletal muscle involvement in patients with chronic alcoholic intoxication |
| title_fullStr | Skeletal muscle involvement in patients with chronic alcoholic intoxication |
| title_full_unstemmed | Skeletal muscle involvement in patients with chronic alcoholic intoxication |
| title_short | Skeletal muscle involvement in patients with chronic alcoholic intoxication |
| title_sort | skeletal muscle involvement in patients with chronic alcoholic intoxication |
| topic | chronic alcoholic myopathy diagnosis muscle biopsy insulin-growth-like growth factor 1 protein synthesis |
| url | https://nnp.ima-press.net/nnp/article/view/175 |
| work_keys_str_mv | AT olgaevgenyevnazinovyeva skeletalmuscleinvolvementinpatientswithchronicalcoholicintoxication AT nsshcheglova skeletalmuscleinvolvementinpatientswithchronicalcoholicintoxication AT yvkazantseva skeletalmuscleinvolvementinpatientswithchronicalcoholicintoxication AT bsshenkman skeletalmuscleinvolvementinpatientswithchronicalcoholicintoxication AT egaltayeva skeletalmuscleinvolvementinpatientswithchronicalcoholicintoxication |