The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome
Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are diseases caused by the interaction of genetic and non-genetic factors. Therefore, the aim of our study was to investigate the association between six common genetic polymorphisms and T2DM and MetS in males. A total of 120 T2DM, 75 Met...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2023-07-01
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| Series: | Balkan Journal of Medical Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/bjmg-2023-0003 |
| _version_ | 1797740360913387520 |
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| author | Zenoaga-Barbăroșie C Berca L Vassu-Dimov T Toma M Nica MI Alexiu-Toma OA Ciornei C Albu A Nica S Nistor C Nica R |
| author_facet | Zenoaga-Barbăroșie C Berca L Vassu-Dimov T Toma M Nica MI Alexiu-Toma OA Ciornei C Albu A Nica S Nistor C Nica R |
| author_sort | Zenoaga-Barbăroșie C |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are diseases caused by the interaction of genetic and non-genetic factors. Therefore, the aim of our study was to investigate the association between six common genetic polymorphisms and T2DM and MetS in males. A total of 120 T2DM, 75 MetS, and 120 healthy controls (HC) were included in the study. ACE ID, eNOS 4a/b, ATR1 A1166C, OXTR (A>G), SOD1 +35A/C, CAT-21A/T gene polymorphisms were genotyped by PCR or PCR-RFLP techniques. T2DM was diagnosed at an earlier age compared to MetS (54 vs 55 years old, p=0.0003) and the difference was greater in carriers of the OXTR G allele (54 vs 56 years old, p=0.0002) or both OXTR G and eNOS b alleles (54 vs 56, p=0.00016). The SOD1 AA genotype (O.R.=0.11, p=0.0006) and the presence of both ACE I and OXTR1 A (O.R.=0.39, p=0.0005) alleles revealed to be protective for T2DM. SOD1 AA and AC genotypes were protective factors for triglyceride (p=0.0002 and p=0.0005, respectively) and HDL cholesterol (p=0.0002 and p=0.0004, respectively) levels in T2DM patients. ACE DD was identified more frequently in hypertensive T2DM patients (O.R.=3.77, p=0.0005) and in those who reported drinking alcohol (p=0.0001) comparing to HC and T2DM patients who did not drink alcohol, respectively. We observed that T2DM patients who reported drinking alcohol had an increased frequency of ACE DD and eNOS bb (p<0.0001), or ACE DD and OXTR G (p<0.0001) compared to non-drinkers. No gene polymorphisms were associated with MetS. |
| first_indexed | 2024-03-12T14:11:20Z |
| format | Article |
| id | doaj.art-1879f9a37de446d593ca9a63b513996f |
| institution | Directory Open Access Journal |
| issn | 2199-5761 |
| language | English |
| last_indexed | 2024-03-12T14:11:20Z |
| publishDate | 2023-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Balkan Journal of Medical Genetics |
| spelling | doaj.art-1879f9a37de446d593ca9a63b513996f2023-08-21T06:43:49ZengSciendoBalkan Journal of Medical Genetics2199-57612023-07-01261212610.2478/bjmg-2023-0003The Predisposition for Type 2 Diabetes Mellitus and Metabolic SyndromeZenoaga-Barbăroșie C0Berca L1Vassu-Dimov T2Toma M3Nica MI4Alexiu-Toma OA5Ciornei C6Albu A7Nica S8Nistor C9Nica R10Department of Genetics, University of Bucharest, Bucharest, RomaniaMolecular Biology Department, National Research and Development Institute for Food Bioresources – IBA Bucharest, Bucharest, RomaniaDepartment of Genetics, University of Bucharest, Bucharest, RomaniaEmergency Department, Central Military Emergency Hospital Dr. Carol Davila, Bucharest, RomaniaUniversity of Medicine and Pharmacy Carol Davila, Bucharest, RomaniaDepartment of Genetics, University of Bucharest, Bucharest, RomaniaPreclinical Department, University of Medicine and Pharmacy Carol Davila, Bucharest, RomaniaEmergency Department, Bucharest Emergency University Hospital, Bucharest, Romania.Emergency Department, Bucharest Emergency University Hospital, Bucharest, Romania.Preclinical Department, University of Medicine and Pharmacy Carol Davila, Bucharest, RomaniaSurgery 2, Central Military Emergency Hospital Dr. Carol Davila, Bucharest, RomaniaType 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are diseases caused by the interaction of genetic and non-genetic factors. Therefore, the aim of our study was to investigate the association between six common genetic polymorphisms and T2DM and MetS in males. A total of 120 T2DM, 75 MetS, and 120 healthy controls (HC) were included in the study. ACE ID, eNOS 4a/b, ATR1 A1166C, OXTR (A>G), SOD1 +35A/C, CAT-21A/T gene polymorphisms were genotyped by PCR or PCR-RFLP techniques. T2DM was diagnosed at an earlier age compared to MetS (54 vs 55 years old, p=0.0003) and the difference was greater in carriers of the OXTR G allele (54 vs 56 years old, p=0.0002) or both OXTR G and eNOS b alleles (54 vs 56, p=0.00016). The SOD1 AA genotype (O.R.=0.11, p=0.0006) and the presence of both ACE I and OXTR1 A (O.R.=0.39, p=0.0005) alleles revealed to be protective for T2DM. SOD1 AA and AC genotypes were protective factors for triglyceride (p=0.0002 and p=0.0005, respectively) and HDL cholesterol (p=0.0002 and p=0.0004, respectively) levels in T2DM patients. ACE DD was identified more frequently in hypertensive T2DM patients (O.R.=3.77, p=0.0005) and in those who reported drinking alcohol (p=0.0001) comparing to HC and T2DM patients who did not drink alcohol, respectively. We observed that T2DM patients who reported drinking alcohol had an increased frequency of ACE DD and eNOS bb (p<0.0001), or ACE DD and OXTR G (p<0.0001) compared to non-drinkers. No gene polymorphisms were associated with MetS.https://doi.org/10.2478/bjmg-2023-0003ace idenos vntr 4a/bmetabolic syndromeoxtr (a>g)sod1 +35a/ctype 2 diabetes mellitus |
| spellingShingle | Zenoaga-Barbăroșie C Berca L Vassu-Dimov T Toma M Nica MI Alexiu-Toma OA Ciornei C Albu A Nica S Nistor C Nica R The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome Balkan Journal of Medical Genetics ace id enos vntr 4a/b metabolic syndrome oxtr (a>g) sod1 +35a/c type 2 diabetes mellitus |
| title | The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome |
| title_full | The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome |
| title_fullStr | The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome |
| title_full_unstemmed | The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome |
| title_short | The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome |
| title_sort | predisposition for type 2 diabetes mellitus and metabolic syndrome |
| topic | ace id enos vntr 4a/b metabolic syndrome oxtr (a>g) sod1 +35a/c type 2 diabetes mellitus |
| url | https://doi.org/10.2478/bjmg-2023-0003 |
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