Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
In this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have emerged, compared to eastern Uganda.
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33873-x |
| _version_ | 1797991601612521472 |
|---|---|
| author | Patrick K. Tumwebaze Melissa D. Conrad Martin Okitwi Stephen Orena Oswald Byaruhanga Thomas Katairo Jennifer Legac Shreeya Garg David Giesbrecht Sawyer R. Smith Frida G. Ceja Samuel L. Nsobya Jeffrey A. Bailey Roland A. Cooper Philip J. Rosenthal |
| author_facet | Patrick K. Tumwebaze Melissa D. Conrad Martin Okitwi Stephen Orena Oswald Byaruhanga Thomas Katairo Jennifer Legac Shreeya Garg David Giesbrecht Sawyer R. Smith Frida G. Ceja Samuel L. Nsobya Jeffrey A. Bailey Roland A. Cooper Philip J. Rosenthal |
| author_sort | Patrick K. Tumwebaze |
| collection | DOAJ |
| description | In this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have emerged, compared to eastern Uganda. |
| first_indexed | 2024-04-11T08:54:48Z |
| format | Article |
| id | doaj.art-187a57e02f454e7cb07950de76fde6a6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T08:54:48Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-187a57e02f454e7cb07950de76fde6a62022-12-22T04:33:20ZengNature PortfolioNature Communications2041-17232022-10-0113111210.1038/s41467-022-33873-xDecreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern UgandaPatrick K. Tumwebaze0Melissa D. Conrad1Martin Okitwi2Stephen Orena3Oswald Byaruhanga4Thomas Katairo5Jennifer Legac6Shreeya Garg7David Giesbrecht8Sawyer R. Smith9Frida G. Ceja10Samuel L. Nsobya11Jeffrey A. Bailey12Roland A. Cooper13Philip J. Rosenthal14Infectious Diseases Research CollaborationUniversity of CaliforniaInfectious Diseases Research CollaborationInfectious Diseases Research CollaborationInfectious Diseases Research CollaborationInfectious Diseases Research CollaborationUniversity of CaliforniaUniversity of CaliforniaBrown UniversityBrown UniversityDominican University of CaliforniaInfectious Diseases Research CollaborationBrown UniversityDominican University of CaliforniaUniversity of CaliforniaIn this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have emerged, compared to eastern Uganda.https://doi.org/10.1038/s41467-022-33873-x |
| spellingShingle | Patrick K. Tumwebaze Melissa D. Conrad Martin Okitwi Stephen Orena Oswald Byaruhanga Thomas Katairo Jennifer Legac Shreeya Garg David Giesbrecht Sawyer R. Smith Frida G. Ceja Samuel L. Nsobya Jeffrey A. Bailey Roland A. Cooper Philip J. Rosenthal Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda Nature Communications |
| title | Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda |
| title_full | Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda |
| title_fullStr | Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda |
| title_full_unstemmed | Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda |
| title_short | Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda |
| title_sort | decreased susceptibility of plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern uganda |
| url | https://doi.org/10.1038/s41467-022-33873-x |
| work_keys_str_mv | AT patrickktumwebaze decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT melissadconrad decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT martinokitwi decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT stephenorena decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT oswaldbyaruhanga decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT thomaskatairo decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT jenniferlegac decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT shreeyagarg decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT davidgiesbrecht decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT sawyerrsmith decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT fridagceja decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT samuellnsobya decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT jeffreyabailey decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT rolandacooper decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda AT philipjrosenthal decreasedsusceptibilityofplasmodiumfalciparumtobothdihydroartemisininandlumefantrineinnorthernuganda |