B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
B-1a B cells are innate-like cells with biased reactivity to bacteria and self-antigens. Here the authors show that reduced interleukin-7 in developing fetal liver-derived pro-B cells induces premature immunoglobulin κ rearrangement, alleviating the requirement for a pre-BCR selection stage and allo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12824-z |
| _version_ | 1818433651083313152 |
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| author | Jason B. Wong Susannah L. Hewitt Lynn M. Heltemes-Harris Malay Mandal Kristen Johnson Klaus Rajewsky Sergei B. Koralov Marcus R. Clark Michael A. Farrar Jane A. Skok |
| author_facet | Jason B. Wong Susannah L. Hewitt Lynn M. Heltemes-Harris Malay Mandal Kristen Johnson Klaus Rajewsky Sergei B. Koralov Marcus R. Clark Michael A. Farrar Jane A. Skok |
| author_sort | Jason B. Wong |
| collection | DOAJ |
| description | B-1a B cells are innate-like cells with biased reactivity to bacteria and self-antigens. Here the authors show that reduced interleukin-7 in developing fetal liver-derived pro-B cells induces premature immunoglobulin κ rearrangement, alleviating the requirement for a pre-BCR selection stage and allowing the generation of autoreactive B1-a B cells. |
| first_indexed | 2024-12-14T16:24:29Z |
| format | Article |
| id | doaj.art-187b8150da99438da49e30693e5b9441 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:24:29Z |
| publishDate | 2019-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-187b8150da99438da49e30693e5b94412022-12-21T22:54:44ZengNature PortfolioNature Communications2041-17232019-10-0110111510.1038/s41467-019-12824-zB-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stageJason B. Wong0Susannah L. Hewitt1Lynn M. Heltemes-Harris2Malay Mandal3Kristen Johnson4Klaus Rajewsky5Sergei B. Koralov6Marcus R. Clark7Michael A. Farrar8Jane A. Skok9Department of Pathology, New York University School of Medicine, New York UniversityDepartment of Pathology, New York University School of Medicine, New York UniversityDepartment of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of MinnesotaDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of ChicagoDepartment of Pathology, New York University School of Medicine, New York UniversityMax Delbrück Center for Molecular MedicineDepartment of Pathology, New York University School of Medicine, New York UniversityDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of ChicagoDepartment of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of MinnesotaDepartment of Pathology, New York University School of Medicine, New York UniversityB-1a B cells are innate-like cells with biased reactivity to bacteria and self-antigens. Here the authors show that reduced interleukin-7 in developing fetal liver-derived pro-B cells induces premature immunoglobulin κ rearrangement, alleviating the requirement for a pre-BCR selection stage and allowing the generation of autoreactive B1-a B cells.https://doi.org/10.1038/s41467-019-12824-z |
| spellingShingle | Jason B. Wong Susannah L. Hewitt Lynn M. Heltemes-Harris Malay Mandal Kristen Johnson Klaus Rajewsky Sergei B. Koralov Marcus R. Clark Michael A. Farrar Jane A. Skok B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage Nature Communications |
| title | B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage |
| title_full | B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage |
| title_fullStr | B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage |
| title_full_unstemmed | B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage |
| title_short | B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage |
| title_sort | b 1a cells acquire their unique characteristics by bypassing the pre bcr selection stage |
| url | https://doi.org/10.1038/s41467-019-12824-z |
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