| Summary: | <p><strong>Objective</strong> To screen the risk factors for recurrence of ischemic stroke and to assess the risk of recurrence. <strong> Methods</strong> Essen Stroke Risk Score (ESRS) was used to evaluate the risk of recurrence in 176 patients with ischemic stroke (96 cases of first onset and 80 cases of recurrence). Univariate and multivariate stepwise Logistic regression analysis was used to screen risk factors for recurrence of ischemic stroke. <strong>Results</strong> There were significant differences between first onset group and recurrence group on age, the proportion of > 75 years old, hypertension, diabetes, coronary heart disease, peripheral angiopathy, transient ischemic attack (TIA) or ischemic stroke, drinking and ESRS score (<em>P</em> < 0.05, for all). First onset group included one case of ESRS 0 (1.04%), 8 cases of 1 (8.33%), 39 cases of 2 (40.63%), 44 cases of 3 (45.83%), 4 cases of 4 (4.17%). Recurrence group included 2 cases of ESRS 3 (2.50%), 20 cases of 4 (25% ), 37 cases of 5 (46.25% ), 18 cases of 6 (22.50% ), 3 cases of 7 (3.75% ). There was significant difference between 2 groups (<em>Z</em> = -11.376, <em>P</em> = 0.000). Logistic regression analysis showed ESRS > 3 score was independent risk factor for recurrence of ischemic stroke (<em>OR</em> = 31.324, 95%CI: 3.934-249.430; <em>P</em> = 0.001). <strong> Conclusions</strong> ESRS > 3 score is the independent risk factor for recurrence of ischemic stroke. It is important to strengthen risk assessment of recurrence of ischemic stroke. To screen and control risk factors is the key to secondary prevention of ischemic stroke.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2016.07.011</p>
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