Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platforms
Monkeypox (Mpox) is a transmissible infection induced by the Monkeypox virus (a double-stranded DNA virus), recognised under the family orthopoxvirus genus. Monkeypox, like endemic diseases, is a substantial concern worldwide; thus, comprehending the pathogenesis and mutagenesis of amino acids is in...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Travel Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1477893923000960 |
| _version_ | 1797398679205707776 |
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| author | Sourav Mohanto Md Faiyazuddin Amol Dilip Gholap Darshan JC Adrija Bhunia Kannan Subbaram Mohammed Gulzar Ahmed Sagnik Nag Mohammad Shabib Akhtar D. Katterine Bonilla-Aldana Sanjit Sah Sumira Malik Zahraa Haleem Al-qaim Joshuan J. Barboza Ranjit Sah |
| author_facet | Sourav Mohanto Md Faiyazuddin Amol Dilip Gholap Darshan JC Adrija Bhunia Kannan Subbaram Mohammed Gulzar Ahmed Sagnik Nag Mohammad Shabib Akhtar D. Katterine Bonilla-Aldana Sanjit Sah Sumira Malik Zahraa Haleem Al-qaim Joshuan J. Barboza Ranjit Sah |
| author_sort | Sourav Mohanto |
| collection | DOAJ |
| description | Monkeypox (Mpox) is a transmissible infection induced by the Monkeypox virus (a double-stranded DNA virus), recognised under the family orthopoxvirus genus. Monkeypox, like endemic diseases, is a substantial concern worldwide; thus, comprehending the pathogenesis and mutagenesis of amino acids is indispensable to combat the infection. According to the World Health Organization's report, about 89 thousand cases with 160 mortalities have been reported from 114 countries worldwide. The conventional orthopoxvirus vaccines developed on live attenuated viruses exempted any clinical validation from combating monkeypox due to inadequate immunogenicity, toxicity, instability, and multiple doses. Therefore, novel drug delivery systems come into the conception with high biological and mechanical characteristics to address the resurgence of Global Monkeypox. The edges of metallic biomaterials, novel molecules, and vaccine development in targeted therapy increase the modulation of the immune response and blockage of host-virus interaction, with enhanced stability for the antigens. Thus, this review strives to comprehend the viral cell pathogenesis concerning amino acid mutagenesis and current epidemiological standards of the Monkeypox disease across the globe. Furthermore, the review also recapitulates the various clinical challenges, current therapies, and progressive nanomedicine utilisation in the Monkeypox outbreak reinforced by various clinical trial reports. The contemporary challenges of novel drug delivery systems in Monkeypox treatment cannot be overlooked, and thus, authors have outlined the future strategies to develop successful nanomedicine to combat monkeypox. Future pandemics are inevitable but can be satisfactorily handled if we comprehend the crises, innovate, and develop cutting-edge technologies, especially by delving into frontiers like nanotechnology. |
| first_indexed | 2024-03-09T01:29:04Z |
| format | Article |
| id | doaj.art-187ff0bfa3344b98bd8722d65bd18e67 |
| institution | Directory Open Access Journal |
| issn | 1873-0442 |
| language | English |
| last_indexed | 2024-03-09T01:29:04Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Travel Medicine and Infectious Disease |
| spelling | doaj.art-187ff0bfa3344b98bd8722d65bd18e672023-12-10T06:13:57ZengElsevierTravel Medicine and Infectious Disease1873-04422023-11-0156102636Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platformsSourav Mohanto0Md Faiyazuddin1Amol Dilip Gholap2Darshan JC3Adrija Bhunia4Kannan Subbaram5Mohammed Gulzar Ahmed6Sagnik Nag7Mohammad Shabib Akhtar8D. Katterine Bonilla-Aldana9Sanjit Sah10Sumira Malik11Zahraa Haleem Al-qaim12Joshuan J. Barboza13Ranjit Sah14Department of Pharmaceutics, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka, 575018, IndiaSchool of Pharmacy, Al-Karim University, Katihar, Bihar, 845106, India; Nano Drug Delivery®, Chapel Hill, NC, USADepartment of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar, Maharashtra, 401404, IndiaDepartment of Pharmacy Practice, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka, 575018, IndiaDepartment of Pharmaceutics, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka, 575018, IndiaSchool of Medicine, The Maldives National University, Male', MaldivesDepartment of Pharmaceutics, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka, 575018, IndiaDepartment of Bio-Sciences, School of Bio-Sciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, IndiaDepartment of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Kingdom of Saudi ArabiaResearch Unit, Universidad Continental, Huancayo, Peru; Corresponding author.Global Consortium for Public Health and Research, Datta Meghe Institute of Higher Education and Research, Jawaharlal Nehru Medical College, Wardha, 442001, India; SR Sanjeevani Hospital, Kalyanpur-10, Siraha, NepalAmity Institute of Biotechnology, Amity University, Jharkhand, 834002, Ranchi, India; School of Applied Sciences, Uttaranchal University, Dehradun, IndiaDepartment of Anesthesia Techniques, Al-Mustaqbal University College, 51001, Hillah, Babylon, IraqEscuela de Medicina, Universidad César Vallejo, Trujillo, 13007, PeruTribhuvan University Teaching Hospital, Kathmandu, 46000, Nepal; Department of Clinical Microbiology, DY Patil Medical College, Hospital and Research Centre, DY Patil Vidyapeeth, Pune, 411000, Maharashtra, India; Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, 411018, Maharashtra, IndiaMonkeypox (Mpox) is a transmissible infection induced by the Monkeypox virus (a double-stranded DNA virus), recognised under the family orthopoxvirus genus. Monkeypox, like endemic diseases, is a substantial concern worldwide; thus, comprehending the pathogenesis and mutagenesis of amino acids is indispensable to combat the infection. According to the World Health Organization's report, about 89 thousand cases with 160 mortalities have been reported from 114 countries worldwide. The conventional orthopoxvirus vaccines developed on live attenuated viruses exempted any clinical validation from combating monkeypox due to inadequate immunogenicity, toxicity, instability, and multiple doses. Therefore, novel drug delivery systems come into the conception with high biological and mechanical characteristics to address the resurgence of Global Monkeypox. The edges of metallic biomaterials, novel molecules, and vaccine development in targeted therapy increase the modulation of the immune response and blockage of host-virus interaction, with enhanced stability for the antigens. Thus, this review strives to comprehend the viral cell pathogenesis concerning amino acid mutagenesis and current epidemiological standards of the Monkeypox disease across the globe. Furthermore, the review also recapitulates the various clinical challenges, current therapies, and progressive nanomedicine utilisation in the Monkeypox outbreak reinforced by various clinical trial reports. The contemporary challenges of novel drug delivery systems in Monkeypox treatment cannot be overlooked, and thus, authors have outlined the future strategies to develop successful nanomedicine to combat monkeypox. Future pandemics are inevitable but can be satisfactorily handled if we comprehend the crises, innovate, and develop cutting-edge technologies, especially by delving into frontiers like nanotechnology.http://www.sciencedirect.com/science/article/pii/S1477893923000960MonkeypoxInfectious diseaseVaccineNanomedicineTreatmentClinical trials |
| spellingShingle | Sourav Mohanto Md Faiyazuddin Amol Dilip Gholap Darshan JC Adrija Bhunia Kannan Subbaram Mohammed Gulzar Ahmed Sagnik Nag Mohammad Shabib Akhtar D. Katterine Bonilla-Aldana Sanjit Sah Sumira Malik Zahraa Haleem Al-qaim Joshuan J. Barboza Ranjit Sah Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platforms Travel Medicine and Infectious Disease Monkeypox Infectious disease Vaccine Nanomedicine Treatment Clinical trials |
| title | Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platforms |
| title_full | Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platforms |
| title_fullStr | Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platforms |
| title_full_unstemmed | Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platforms |
| title_short | Addressing the resurgence of global monkeypox (Mpox) through advanced drug delivery platforms |
| title_sort | addressing the resurgence of global monkeypox mpox through advanced drug delivery platforms |
| topic | Monkeypox Infectious disease Vaccine Nanomedicine Treatment Clinical trials |
| url | http://www.sciencedirect.com/science/article/pii/S1477893923000960 |
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