Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review
Abstract Background Exhaled biomarkers may be related to disease processes in idiopathic pulmonary fibrosis (IPF) however their clinical role remains unclear. We performed a systematic review to investigate whether breath biomarkers discriminate between patients with IPF and healthy controls. We als...
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12931-019-0971-8 |
| _version_ | 1818110117819711488 |
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| author | Conal Hayton Dayle Terrington Andrew M. Wilson Nazia Chaudhuri Colm Leonard Stephen J. Fowler |
| author_facet | Conal Hayton Dayle Terrington Andrew M. Wilson Nazia Chaudhuri Colm Leonard Stephen J. Fowler |
| author_sort | Conal Hayton |
| collection | DOAJ |
| description | Abstract Background Exhaled biomarkers may be related to disease processes in idiopathic pulmonary fibrosis (IPF) however their clinical role remains unclear. We performed a systematic review to investigate whether breath biomarkers discriminate between patients with IPF and healthy controls. We also assessed correlation with lung function, ability to distinguish diagnostic subgroups and change in response to treatment. Methods MEDLINE, EMBASE and Web of Science databases were searched. Study selection was limited to adults with a diagnosis of IPF as per international guidelines. Results Of 1014 studies screened, fourteen fulfilled selection criteria and included 257 IPF patients. Twenty individual biomarkers discriminated between IPF and controls and four showed correlation with lung function. Meta-analysis of three studies indicated mean (± SD) alveolar nitric oxide (CalvNO) levels were significantly higher in IPF (8.5 ± 5.5 ppb) than controls (4.4 ± 2.2 ppb). Markers of oxidative stress in exhaled breath condensate, such as hydrogen peroxide and 8-isoprostane, were also discriminatory. Two breathomic studies have isolated discriminative compounds using mass spectrometry. There was a lack of studies assessing relevant treatment and none assessed differences in diagnostic subgroups. Conclusions Evidence suggests CalvNO is higher in IPF, although studies were limited by small sample size. Further breathomic work may identify biomarkers with diagnostic and prognostic potential. |
| first_indexed | 2024-12-11T02:42:03Z |
| format | Article |
| id | doaj.art-18820c142f2e4e389367c9a15eb696a6 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-11T02:42:03Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-18820c142f2e4e389367c9a15eb696a62022-12-22T01:23:31ZengBMCRespiratory Research1465-993X2019-01-0120111610.1186/s12931-019-0971-8Breath biomarkers in idiopathic pulmonary fibrosis: a systematic reviewConal Hayton0Dayle Terrington1Andrew M. Wilson2Nazia Chaudhuri3Colm Leonard4Stephen J. Fowler5Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of ManchesterNorwich Medical School, University of East AngliaNorwich Medical School, University of East AngliaNorth West Lung Centre, Manchester University NHS Foundation TrustNorth West Lung Centre, Manchester University NHS Foundation TrustDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of ManchesterAbstract Background Exhaled biomarkers may be related to disease processes in idiopathic pulmonary fibrosis (IPF) however their clinical role remains unclear. We performed a systematic review to investigate whether breath biomarkers discriminate between patients with IPF and healthy controls. We also assessed correlation with lung function, ability to distinguish diagnostic subgroups and change in response to treatment. Methods MEDLINE, EMBASE and Web of Science databases were searched. Study selection was limited to adults with a diagnosis of IPF as per international guidelines. Results Of 1014 studies screened, fourteen fulfilled selection criteria and included 257 IPF patients. Twenty individual biomarkers discriminated between IPF and controls and four showed correlation with lung function. Meta-analysis of three studies indicated mean (± SD) alveolar nitric oxide (CalvNO) levels were significantly higher in IPF (8.5 ± 5.5 ppb) than controls (4.4 ± 2.2 ppb). Markers of oxidative stress in exhaled breath condensate, such as hydrogen peroxide and 8-isoprostane, were also discriminatory. Two breathomic studies have isolated discriminative compounds using mass spectrometry. There was a lack of studies assessing relevant treatment and none assessed differences in diagnostic subgroups. Conclusions Evidence suggests CalvNO is higher in IPF, although studies were limited by small sample size. Further breathomic work may identify biomarkers with diagnostic and prognostic potential.http://link.springer.com/article/10.1186/s12931-019-0971-8Idiopathic pulmonary fibrosisBreath testsNitric oxideVolatile organic compoundsExhaled breath condensate |
| spellingShingle | Conal Hayton Dayle Terrington Andrew M. Wilson Nazia Chaudhuri Colm Leonard Stephen J. Fowler Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review Respiratory Research Idiopathic pulmonary fibrosis Breath tests Nitric oxide Volatile organic compounds Exhaled breath condensate |
| title | Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review |
| title_full | Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review |
| title_fullStr | Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review |
| title_full_unstemmed | Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review |
| title_short | Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review |
| title_sort | breath biomarkers in idiopathic pulmonary fibrosis a systematic review |
| topic | Idiopathic pulmonary fibrosis Breath tests Nitric oxide Volatile organic compounds Exhaled breath condensate |
| url | http://link.springer.com/article/10.1186/s12931-019-0971-8 |
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