Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I

Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I

Respiratory complex I performs the reduction of quinone (Q) to quinol (QH2) and pumps protons across the membrane. Structural data on complex I have provided spectacular insights into the electron and proton transfer paths, as well as into the long (~30 Å) and unique substrate binding channel. Howev...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Outi Haapanen, Amina Djurabekova, Vivek Sharma
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2019-04-01
Schriftenreihe:Frontiers in Chemistry
Schlagworte:
redox chemistry
proton transport
electron transport
density functional calculations
molecular dynamics
cell respiration
Online Zugang:https://www.frontiersin.org/article/10.3389/fchem.2019.00221/full

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