A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus

A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus

Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) affect over one-half of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that SLE-prone mice (CReCOM) develop NP-SLE, including behavioral deficits prior to systemic autoimmunity, reduced brain volumes,...

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Bibliographic Details
Main Authors: Hadijat M. Makinde, Deborah R. Winter, Daniele Procissi, Elise V. Mike, Ariel D. Stock, Mary J. Kando, Gaurav T. Gadhvi, Steven Droho, Christina L. Bloomfield, Salina T. Dominguez, Maximilian G. Mayr, Jeremy A. Lavine, Chaim Putterman, Carla M. Cuda
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
lupus
SLE
NP-SLE
behavior
microglia
DAM
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00230/full

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