TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication
The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple diseases including cancer. With hormone-driven...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1517 |
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| author | Eleonora Pauletto Nils Eickhoff Nuno A. Padrão Christine Blattner Wilbert Zwart |
| author_facet | Eleonora Pauletto Nils Eickhoff Nuno A. Padrão Christine Blattner Wilbert Zwart |
| author_sort | Eleonora Pauletto |
| collection | DOAJ |
| description | The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple diseases including cancer. With hormone-driven cancers being among the leading causes of cancer-related death, TRIM proteins have been described to portrait tumor suppressive or oncogenic activities in these tumor types. This review describes the biological impact of TRIM proteins in relation to hormone receptor biology, as well as hormone-independent mechanisms that contribute to tumor cell biology in prostate, breast, ovarian and endometrial cancer. Furthermore, we point out common functions of TRIM proteins throughout the group of hormone-driven cancers. An improved understanding of the biological impact of TRIM proteins in cancer may pave the way for improved prognostication and novel therapeutics, ultimately improving cancer care for patients with hormone-driven cancers. |
| first_indexed | 2024-03-10T10:21:08Z |
| format | Article |
| id | doaj.art-1884d0d3abaf478b94ed85a049b268df |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:21:08Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1884d0d3abaf478b94ed85a049b268df2023-11-22T00:22:02ZengMDPI AGCells2073-44092021-06-01106151710.3390/cells10061517TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and PrognosticationEleonora Pauletto0Nils Eickhoff1Nuno A. Padrão2Christine Blattner3Wilbert Zwart4Institute of Biological and Chemical Systems-Biological Information Processing, Karlsruhe Institute of Technology, PO-Box 3640, 76021 Karlsruhe, GermanyDivision of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066CX Amsterdam, The NetherlandsDivision of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066CX Amsterdam, The NetherlandsInstitute of Biological and Chemical Systems-Biological Information Processing, Karlsruhe Institute of Technology, PO-Box 3640, 76021 Karlsruhe, GermanyDivision of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066CX Amsterdam, The NetherlandsThe tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple diseases including cancer. With hormone-driven cancers being among the leading causes of cancer-related death, TRIM proteins have been described to portrait tumor suppressive or oncogenic activities in these tumor types. This review describes the biological impact of TRIM proteins in relation to hormone receptor biology, as well as hormone-independent mechanisms that contribute to tumor cell biology in prostate, breast, ovarian and endometrial cancer. Furthermore, we point out common functions of TRIM proteins throughout the group of hormone-driven cancers. An improved understanding of the biological impact of TRIM proteins in cancer may pave the way for improved prognostication and novel therapeutics, ultimately improving cancer care for patients with hormone-driven cancers.https://www.mdpi.com/2073-4409/10/6/1517TRIM proteinshormone-related cancersE3 ligasesubiquitinRINGsteroid hormones |
| spellingShingle | Eleonora Pauletto Nils Eickhoff Nuno A. Padrão Christine Blattner Wilbert Zwart TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication Cells TRIM proteins hormone-related cancers E3 ligases ubiquitin RING steroid hormones |
| title | TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication |
| title_full | TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication |
| title_fullStr | TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication |
| title_full_unstemmed | TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication |
| title_short | TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication |
| title_sort | trimming down hormone driven cancers the biological impact of trim proteins on tumor development progression and prognostication |
| topic | TRIM proteins hormone-related cancers E3 ligases ubiquitin RING steroid hormones |
| url | https://www.mdpi.com/2073-4409/10/6/1517 |
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