Role of gut microbiota in the modulation of atherosclerosis-associated immune response
Inflammation and metabolic abnormalities are linked to each other. At present, pathogenic inflammatory response was recognized as a major player in metabolic diseases. In humans, intestinal microflora could significantly influence the development of metabolic diseases including atherosclerosis. Comm...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-06-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00671/full |
| _version_ | 1818924647143440384 |
|---|---|
| author | Dimitry A Chistiakov Yuri V Bobryshev Emil eKozarov Igor A Sobenin Alexander N. Orekhov |
| author_facet | Dimitry A Chistiakov Yuri V Bobryshev Emil eKozarov Igor A Sobenin Alexander N. Orekhov |
| author_sort | Dimitry A Chistiakov |
| collection | DOAJ |
| description | Inflammation and metabolic abnormalities are linked to each other. At present, pathogenic inflammatory response was recognized as a major player in metabolic diseases. In humans, intestinal microflora could significantly influence the development of metabolic diseases including atherosclerosis. Commensal bacteria were shown to activate inflammatory pathways through altering lipid metabolism in adipocytes, macrophages, and vascular cells, inducing insulin resistance, and producing trimethylamine-N-oxide. However, gut microbiota could also play the atheroprotective role associated with anthocyanin metabolism and administration of probiotics and their components. Here, we review the mechanisms by which the gut microbiota may influence atherogenesis. |
| first_indexed | 2024-12-20T02:28:39Z |
| format | Article |
| id | doaj.art-188716454e0f4fb9a852461f3594fe4b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T02:28:39Z |
| publishDate | 2015-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-188716454e0f4fb9a852461f3594fe4b2022-12-21T19:56:38ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-06-01610.3389/fmicb.2015.00671131980Role of gut microbiota in the modulation of atherosclerosis-associated immune responseDimitry A Chistiakov0Yuri V Bobryshev1Emil eKozarov2Igor A Sobenin3Alexander N. Orekhov4Research Center for Children’s HealthUniversity of New South Wales and University of Western SydneyColumbia UniversityRussian Cardiology Research and Production ComplexInstitute of General Pathology and PathophysiologyInflammation and metabolic abnormalities are linked to each other. At present, pathogenic inflammatory response was recognized as a major player in metabolic diseases. In humans, intestinal microflora could significantly influence the development of metabolic diseases including atherosclerosis. Commensal bacteria were shown to activate inflammatory pathways through altering lipid metabolism in adipocytes, macrophages, and vascular cells, inducing insulin resistance, and producing trimethylamine-N-oxide. However, gut microbiota could also play the atheroprotective role associated with anthocyanin metabolism and administration of probiotics and their components. Here, we review the mechanisms by which the gut microbiota may influence atherogenesis.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00671/fullArteriesAtherosclerosisImmune Systematherogenesisintestinal microbiota |
| spellingShingle | Dimitry A Chistiakov Yuri V Bobryshev Emil eKozarov Igor A Sobenin Alexander N. Orekhov Role of gut microbiota in the modulation of atherosclerosis-associated immune response Frontiers in Microbiology Arteries Atherosclerosis Immune System atherogenesis intestinal microbiota |
| title | Role of gut microbiota in the modulation of atherosclerosis-associated immune response |
| title_full | Role of gut microbiota in the modulation of atherosclerosis-associated immune response |
| title_fullStr | Role of gut microbiota in the modulation of atherosclerosis-associated immune response |
| title_full_unstemmed | Role of gut microbiota in the modulation of atherosclerosis-associated immune response |
| title_short | Role of gut microbiota in the modulation of atherosclerosis-associated immune response |
| title_sort | role of gut microbiota in the modulation of atherosclerosis associated immune response |
| topic | Arteries Atherosclerosis Immune System atherogenesis intestinal microbiota |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00671/full |
| work_keys_str_mv | AT dimitryachistiakov roleofgutmicrobiotainthemodulationofatherosclerosisassociatedimmuneresponse AT yurivbobryshev roleofgutmicrobiotainthemodulationofatherosclerosisassociatedimmuneresponse AT emilekozarov roleofgutmicrobiotainthemodulationofatherosclerosisassociatedimmuneresponse AT igorasobenin roleofgutmicrobiotainthemodulationofatherosclerosisassociatedimmuneresponse AT alexandernorekhov roleofgutmicrobiotainthemodulationofatherosclerosisassociatedimmuneresponse |