Fabrication and Properties of Silica Gel/Calcium Sulfate/Strontium-doped β-tricalcium Phosphate Composite Porous Scaffolds for Bone Tissue Engineering
The calcium sulfate/strontium-doped β-tricalcium phosphate composite spherical pellets was fabricated, using the calcium sulfate/strontium-doped β-TCP as raw material, and through the stirring spray drying method, and then composite spherical pellets were combined with silica gel, porous silica gel/...
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| Format: | Article |
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Journal of Materials Engineering
2018-03-01
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| Series: | Cailiao gongcheng |
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| Online Access: | http://jme.biam.ac.cn/CN/Y2018/V46/I3/34 |
| _version_ | 1828078078553751552 |
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| author | QIN Xiao-su HUANG Jie GUO Hua-chao YANG Ze-bin CHEN Qing-hua YAN Ting-ting |
| author_facet | QIN Xiao-su HUANG Jie GUO Hua-chao YANG Ze-bin CHEN Qing-hua YAN Ting-ting |
| author_sort | QIN Xiao-su |
| collection | DOAJ |
| description | The calcium sulfate/strontium-doped β-tricalcium phosphate composite spherical pellets was fabricated, using the calcium sulfate/strontium-doped β-TCP as raw material, and through the stirring spray drying method, and then composite spherical pellets were combined with silica gel, porous silica gel/calcium sulfate/strontium-doped β-tricalcium phosphate scaffold was obtained by stacking aggregation method in the mould. The XRD, SEM and FT-IR, <i>etc</i> are employed to examine the chemical composition, composite morphology and structure characteristics, and the degradability, porosity, mechanical properties and cytotoxicity of the scaffolds materials were studied. The results reveal that the composite porous scaffolds have irregular pore structure with pore size between 0.2-1.0mm, and they have a large number of micropores on each of the composite spherical pellets, with the aperture between 50-200<i>μ</i>m. Moreover, the porosity of the composite scaffolds is about 62%, which can meet the requirements of scaffolds for bone tissue engineering in porosity; the cytotoxicity tests show the composite scaffolds have no cytotoxic effect and it has good degradation. Therefore, it has good application prospect in bone tissue engineering of the bone defect repair of non-bearing site. |
| first_indexed | 2024-04-11T02:41:53Z |
| format | Article |
| id | doaj.art-1887844c39974582bfbf0f5bd4e53780 |
| institution | Directory Open Access Journal |
| issn | 1001-4381 1001-4381 |
| language | zho |
| last_indexed | 2024-04-11T02:41:53Z |
| publishDate | 2018-03-01 |
| publisher | Journal of Materials Engineering |
| record_format | Article |
| series | Cailiao gongcheng |
| spelling | doaj.art-1887844c39974582bfbf0f5bd4e537802023-01-02T18:50:37ZzhoJournal of Materials EngineeringCailiao gongcheng1001-43811001-43812018-03-01463344010.11868/j.issn.1001-4381.2017.001098201803001098Fabrication and Properties of Silica Gel/Calcium Sulfate/Strontium-doped β-tricalcium Phosphate Composite Porous Scaffolds for Bone Tissue EngineeringQIN Xiao-su0HUANG Jie1GUO Hua-chao2YANG Ze-bin3CHEN Qing-hua4YAN Ting-ting5Faculty of Material Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Material Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Material Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Material Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Material Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Material Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaThe calcium sulfate/strontium-doped β-tricalcium phosphate composite spherical pellets was fabricated, using the calcium sulfate/strontium-doped β-TCP as raw material, and through the stirring spray drying method, and then composite spherical pellets were combined with silica gel, porous silica gel/calcium sulfate/strontium-doped β-tricalcium phosphate scaffold was obtained by stacking aggregation method in the mould. The XRD, SEM and FT-IR, <i>etc</i> are employed to examine the chemical composition, composite morphology and structure characteristics, and the degradability, porosity, mechanical properties and cytotoxicity of the scaffolds materials were studied. The results reveal that the composite porous scaffolds have irregular pore structure with pore size between 0.2-1.0mm, and they have a large number of micropores on each of the composite spherical pellets, with the aperture between 50-200<i>μ</i>m. Moreover, the porosity of the composite scaffolds is about 62%, which can meet the requirements of scaffolds for bone tissue engineering in porosity; the cytotoxicity tests show the composite scaffolds have no cytotoxic effect and it has good degradation. Therefore, it has good application prospect in bone tissue engineering of the bone defect repair of non-bearing site.http://jme.biam.ac.cn/CN/Y2018/V46/I3/34silica gelstrontium-doped β-tricalcium phosphatecalcium sulfatecomposite spherical pelletporous scaffold |
| spellingShingle | QIN Xiao-su HUANG Jie GUO Hua-chao YANG Ze-bin CHEN Qing-hua YAN Ting-ting Fabrication and Properties of Silica Gel/Calcium Sulfate/Strontium-doped β-tricalcium Phosphate Composite Porous Scaffolds for Bone Tissue Engineering Cailiao gongcheng silica gel strontium-doped β-tricalcium phosphate calcium sulfate composite spherical pellet porous scaffold |
| title | Fabrication and Properties of Silica Gel/Calcium Sulfate/Strontium-doped β-tricalcium Phosphate Composite Porous Scaffolds for Bone Tissue Engineering |
| title_full | Fabrication and Properties of Silica Gel/Calcium Sulfate/Strontium-doped β-tricalcium Phosphate Composite Porous Scaffolds for Bone Tissue Engineering |
| title_fullStr | Fabrication and Properties of Silica Gel/Calcium Sulfate/Strontium-doped β-tricalcium Phosphate Composite Porous Scaffolds for Bone Tissue Engineering |
| title_full_unstemmed | Fabrication and Properties of Silica Gel/Calcium Sulfate/Strontium-doped β-tricalcium Phosphate Composite Porous Scaffolds for Bone Tissue Engineering |
| title_short | Fabrication and Properties of Silica Gel/Calcium Sulfate/Strontium-doped β-tricalcium Phosphate Composite Porous Scaffolds for Bone Tissue Engineering |
| title_sort | fabrication and properties of silica gel calcium sulfate strontium doped β tricalcium phosphate composite porous scaffolds for bone tissue engineering |
| topic | silica gel strontium-doped β-tricalcium phosphate calcium sulfate composite spherical pellet porous scaffold |
| url | http://jme.biam.ac.cn/CN/Y2018/V46/I3/34 |
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