Synthesis of New Nucleoside Analogues From Benzimidazole and Evaluation of Their Antimicrobial Activity
Our goal in this research, some new nucleoside analogues was synthesized. Starting from ?-D glucose which was converted to per acetylated ?-D gluco pyronoside then converted to active from(1-Bromo Sugar (2) as a sugar moiety.The base moiety 2-substituted benzimidazole was prepared from condensation...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Arabic |
| Published: |
College of Science for Women, University of Baghdad
2016-06-01
|
| Series: | Baghdad Science Journal |
| Subjects: | |
| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2777 |
| _version_ | 1818473156208230400 |
|---|---|
| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | Our goal in this research, some new nucleoside analogues was synthesized. Starting from ?-D glucose which was converted to per acetylated ?-D gluco pyronoside then converted to active from(1-Bromo Sugar (2) as a sugar moiety.The base moiety 2-substituted benzimidazole was prepared from condensation of phenylene diamine with different aromatic aldehydes, which were subjected to amino alkylation via Mannich reaction forming new nucleobase derivatives.
Condensation of nucleobase with bromo sugar through nucleophilic substitution of anomeric carbon with nitrogen forming new protected nucleoside analogues then hydrolyzed with sodium methoxide in methanol to obtain our target, the free nucleoside analogues.
All prepared compound were identified by FT-IR Spectroscopy and some of them with H1 –NMR and C13-NMR Spectroscopy.
The synthesized nucleoside analogues were screened for their antibacterial activity in vitro against four types of bacteria including, Bacillus Staphylococcus, aureus (Gram Positive), E.Coli and Pseudoman as (Gram Negative).Also were screened against four types of Fungi (Aspergines flurs, Aspergillus fumgntnts, Aspergillus niger and pencillum). |
| first_indexed | 2024-04-14T04:18:09Z |
| format | Article |
| id | doaj.art-1888a46b338042b492a36ed7cd68bff7 |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-04-14T04:18:09Z |
| publishDate | 2016-06-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-1888a46b338042b492a36ed7cd68bff72022-12-22T02:12:37ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862016-06-0113210.21123/bsj.13.2.317-332Synthesis of New Nucleoside Analogues From Benzimidazole and Evaluation of Their Antimicrobial ActivityBaghdad Science JournalOur goal in this research, some new nucleoside analogues was synthesized. Starting from ?-D glucose which was converted to per acetylated ?-D gluco pyronoside then converted to active from(1-Bromo Sugar (2) as a sugar moiety.The base moiety 2-substituted benzimidazole was prepared from condensation of phenylene diamine with different aromatic aldehydes, which were subjected to amino alkylation via Mannich reaction forming new nucleobase derivatives. Condensation of nucleobase with bromo sugar through nucleophilic substitution of anomeric carbon with nitrogen forming new protected nucleoside analogues then hydrolyzed with sodium methoxide in methanol to obtain our target, the free nucleoside analogues. All prepared compound were identified by FT-IR Spectroscopy and some of them with H1 –NMR and C13-NMR Spectroscopy. The synthesized nucleoside analogues were screened for their antibacterial activity in vitro against four types of bacteria including, Bacillus Staphylococcus, aureus (Gram Positive), E.Coli and Pseudoman as (Gram Negative).Also were screened against four types of Fungi (Aspergines flurs, Aspergillus fumgntnts, Aspergillus niger and pencillum).http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2777"Nucloside analogues, Benzimidazole" |
| spellingShingle | Baghdad Science Journal Synthesis of New Nucleoside Analogues From Benzimidazole and Evaluation of Their Antimicrobial Activity Baghdad Science Journal "Nucloside analogues, Benzimidazole" |
| title | Synthesis of New Nucleoside Analogues From Benzimidazole and Evaluation of Their Antimicrobial Activity |
| title_full | Synthesis of New Nucleoside Analogues From Benzimidazole and Evaluation of Their Antimicrobial Activity |
| title_fullStr | Synthesis of New Nucleoside Analogues From Benzimidazole and Evaluation of Their Antimicrobial Activity |
| title_full_unstemmed | Synthesis of New Nucleoside Analogues From Benzimidazole and Evaluation of Their Antimicrobial Activity |
| title_short | Synthesis of New Nucleoside Analogues From Benzimidazole and Evaluation of Their Antimicrobial Activity |
| title_sort | synthesis of new nucleoside analogues from benzimidazole and evaluation of their antimicrobial activity |
| topic | "Nucloside analogues, Benzimidazole" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2777 |
| work_keys_str_mv | AT baghdadsciencejournal synthesisofnewnucleosideanaloguesfrombenzimidazoleandevaluationoftheirantimicrobialactivity |