Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification
The aim of this study is to report on the oral lesions detected in 123 patients diagnosed at the University Hospital of Bari from October 2020 to December 2020, focusing on the correlation of clinical and pathological features in order to purpose a new classification. Methods. General and specialist...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/4/757 |
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| author | Gianfranco Favia Angela Tempesta Giuseppe Barile Nicola Brienza Saverio Capodiferro Maria Concetta Vestito Lucilla Crudele Vito Procacci Giuseppe Ingravallo Eugenio Maiorano Luisa Limongelli |
| author_facet | Gianfranco Favia Angela Tempesta Giuseppe Barile Nicola Brienza Saverio Capodiferro Maria Concetta Vestito Lucilla Crudele Vito Procacci Giuseppe Ingravallo Eugenio Maiorano Luisa Limongelli |
| author_sort | Gianfranco Favia |
| collection | DOAJ |
| description | The aim of this study is to report on the oral lesions detected in 123 patients diagnosed at the University Hospital of Bari from October 2020 to December 2020, focusing on the correlation of clinical and pathological features in order to purpose a new classification. Methods. General and specialistic anamnesis were achieved and oral examination was performed. The following data were collected: age/gender, general symptoms and form of Covid-19, presence and features of taste disorders, day of appearance of the oral lesions, type and features of oral lesions and day of beginning of therapies. If ulcerative lesions did not heal, biopsy was performed. Results. Many types of oral lesions were found and classified into four groups considering the timing of appearance and the start of the therapies. Early lesions in the initial stages of Covid-19 before the start of therapies was observed in 65.9% of the patients. In the histopathological analysis of four early lesions, thrombosis of small and middle size vessels was always noticed with necrosis of superficial tissues. Conclusion. The presence of oral lesions in early stages of Covid-19 could represent an initial sign of peripheral thrombosis, a warning sign of possible evolution to severe illness. This suggests that anticoagulant therapies should start as soon as possible. |
| first_indexed | 2024-03-09T00:54:12Z |
| format | Article |
| id | doaj.art-188cc804492548b586e5046c1600f1dd |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T00:54:12Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-188cc804492548b586e5046c1600f1dd2023-12-11T16:59:28ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110475710.3390/jcm10040757Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New ClassificationGianfranco Favia0Angela Tempesta1Giuseppe Barile2Nicola Brienza3Saverio Capodiferro4Maria Concetta Vestito5Lucilla Crudele6Vito Procacci7Giuseppe Ingravallo8Eugenio Maiorano9Luisa Limongelli10Odontostomatology Unit, Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyOdontostomatology Unit, Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyOdontostomatology Unit, Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyCovid-19 Intensive Care Unit, Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyOdontostomatology Unit, Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyCovid-19 Intensive Care Unit, Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyCovid-19 Emergency Unit, Department of Emergency and Urgency, University Hospital Policlinic of Bari, 70124 Bari, ItalyCovid-19 Emergency Unit, Department of Emergency and Urgency, University Hospital Policlinic of Bari, 70124 Bari, ItalyPathological Anatomy Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, ItalyPathological Anatomy Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, ItalyOdontostomatology Unit, Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyThe aim of this study is to report on the oral lesions detected in 123 patients diagnosed at the University Hospital of Bari from October 2020 to December 2020, focusing on the correlation of clinical and pathological features in order to purpose a new classification. Methods. General and specialistic anamnesis were achieved and oral examination was performed. The following data were collected: age/gender, general symptoms and form of Covid-19, presence and features of taste disorders, day of appearance of the oral lesions, type and features of oral lesions and day of beginning of therapies. If ulcerative lesions did not heal, biopsy was performed. Results. Many types of oral lesions were found and classified into four groups considering the timing of appearance and the start of the therapies. Early lesions in the initial stages of Covid-19 before the start of therapies was observed in 65.9% of the patients. In the histopathological analysis of four early lesions, thrombosis of small and middle size vessels was always noticed with necrosis of superficial tissues. Conclusion. The presence of oral lesions in early stages of Covid-19 could represent an initial sign of peripheral thrombosis, a warning sign of possible evolution to severe illness. This suggests that anticoagulant therapies should start as soon as possible.https://www.mdpi.com/2077-0383/10/4/757Covid-19oral lesionsoral ulcersclassification |
| spellingShingle | Gianfranco Favia Angela Tempesta Giuseppe Barile Nicola Brienza Saverio Capodiferro Maria Concetta Vestito Lucilla Crudele Vito Procacci Giuseppe Ingravallo Eugenio Maiorano Luisa Limongelli Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification Journal of Clinical Medicine Covid-19 oral lesions oral ulcers classification |
| title | Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification |
| title_full | Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification |
| title_fullStr | Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification |
| title_full_unstemmed | Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification |
| title_short | Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification |
| title_sort | covid 19 symptomatic patients with oral lesions clinical and histopathological study on 123 cases of the university hospital policlinic of bari with a purpose of a new classification |
| topic | Covid-19 oral lesions oral ulcers classification |
| url | https://www.mdpi.com/2077-0383/10/4/757 |
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