Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI. We examined a novel hypothesis: caspase 1 and caspase 11 serve as danger-associated molecular pattern (DAMPs) sensors in I...

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Bibliographic Details
Main Authors: Alexander M. Fagenson, Keman Xu, Fatma Saaoud, Gayani Nanayakkara, Nirag C. Jhala, Lu Liu, Charles Drummer, Yu Sun, Kwan N. Lau, Antonio Di Carlo, Xiaohua Jiang, Hong Wang, Sunil S. Karhadkar, Xiaofeng Yang
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pathogens
Subjects:
ischemia reperfusion injury
caspase 1
caspase 11
inflammasomes
trained immunity
Online Access:https://www.mdpi.com/2076-0817/9/11/879

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