Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art
Within recent decades, the development of nanotechnology has made a significant contribution to the progress of various fields of study, including the domains of medical and pharmaceutical sciences. A substantially transformed arena within the context of the latter is the development and production...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/6/510 |
| _version_ | 1797566212696178688 |
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| author | Maryam A. Shetab Boushehri Dirk Dietrich Alf Lamprecht |
| author_facet | Maryam A. Shetab Boushehri Dirk Dietrich Alf Lamprecht |
| author_sort | Maryam A. Shetab Boushehri |
| collection | DOAJ |
| description | Within recent decades, the development of nanotechnology has made a significant contribution to the progress of various fields of study, including the domains of medical and pharmaceutical sciences. A substantially transformed arena within the context of the latter is the development and production of various injectable parenteral formulations. Indeed, recent decades have witnessed a rapid growth of the marketed and pipeline nanotechnology-based injectable products, which is a testimony to the remarkability of the aforementioned contribution. Adjunct to the ability of nanomaterials to deliver the incorporated payloads to many different targets of interest, nanotechnology has substantially assisted to the development of many further facets of the art. Such contributions include the enhancement of the drug solubility, development of long-acting locally and systemically injectable formulations, tuning the onset of the drug’s release through the endowment of sensitivity to various internal or external stimuli, as well as adjuvancy and immune activation, which is a desirable component for injectable vaccines and immunotherapeutic formulations. The current work seeks to provide a comprehensive review of all the abovementioned contributions, along with the most recent advances made within each domain. Furthermore, recent developments within the domains of passive and active targeting will be briefly debated. |
| first_indexed | 2024-03-10T19:23:29Z |
| format | Article |
| id | doaj.art-188d90e73b664c69a36c5897c81c36ea |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T19:23:29Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-188d90e73b664c69a36c5897c81c36ea2023-11-20T02:42:35ZengMDPI AGPharmaceutics1999-49232020-06-0112651010.3390/pharmaceutics12060510Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the ArtMaryam A. Shetab Boushehri0Dirk Dietrich1Alf Lamprecht2Department of Pharmaceutics, Faculty of Pharmacy, University of Bonn, 53121 Bonn, GermanyDepartment of Neurosurgery, University Clinic of Bonn, 53105 Bonn, GermanyDepartment of Pharmaceutics, Faculty of Pharmacy, University of Bonn, 53121 Bonn, GermanyWithin recent decades, the development of nanotechnology has made a significant contribution to the progress of various fields of study, including the domains of medical and pharmaceutical sciences. A substantially transformed arena within the context of the latter is the development and production of various injectable parenteral formulations. Indeed, recent decades have witnessed a rapid growth of the marketed and pipeline nanotechnology-based injectable products, which is a testimony to the remarkability of the aforementioned contribution. Adjunct to the ability of nanomaterials to deliver the incorporated payloads to many different targets of interest, nanotechnology has substantially assisted to the development of many further facets of the art. Such contributions include the enhancement of the drug solubility, development of long-acting locally and systemically injectable formulations, tuning the onset of the drug’s release through the endowment of sensitivity to various internal or external stimuli, as well as adjuvancy and immune activation, which is a desirable component for injectable vaccines and immunotherapeutic formulations. The current work seeks to provide a comprehensive review of all the abovementioned contributions, along with the most recent advances made within each domain. Furthermore, recent developments within the domains of passive and active targeting will be briefly debated.https://www.mdpi.com/1999-4923/12/6/510nanotechnologyinjectable parenteral formulationssolubility enhancementcontrolled releasetargetingadjuvancy |
| spellingShingle | Maryam A. Shetab Boushehri Dirk Dietrich Alf Lamprecht Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art Pharmaceutics nanotechnology injectable parenteral formulations solubility enhancement controlled release targeting adjuvancy |
| title | Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art |
| title_full | Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art |
| title_fullStr | Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art |
| title_full_unstemmed | Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art |
| title_short | Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art |
| title_sort | nanotechnology as a platform for the development of injectable parenteral formulations a comprehensive review of the know hows and state of the art |
| topic | nanotechnology injectable parenteral formulations solubility enhancement controlled release targeting adjuvancy |
| url | https://www.mdpi.com/1999-4923/12/6/510 |
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