Comparison between two medical drugs' effect on the crushed sciatic nerve healing in dogs
This article was conducted to evaluate the role of therankeron and methylprednisolone on the healing and regeneration process of the damaged sciatic nerve by crushing in dogs. Eighteen adult dogs were used. The animals were divided into three equal groups. The sciatic nerve of the left hind limb in...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2024-01-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.vetmedmosul.com/article_181351_d9ca65a459e92e369113581530c0a705.pdf |
| _version_ | 1797370989535821824 |
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| author | Osama H. Al-Hyani Ahmed Kh. Ali Ahmed M. Al-Saidya Hana Kh. Ismail |
| author_facet | Osama H. Al-Hyani Ahmed Kh. Ali Ahmed M. Al-Saidya Hana Kh. Ismail |
| author_sort | Osama H. Al-Hyani |
| collection | DOAJ |
| description | This article was conducted to evaluate the role of therankeron and methylprednisolone on the healing and regeneration process of the damaged sciatic nerve by crushing in dogs. Eighteen adult dogs were used. The animals were divided into three equal groups. The sciatic nerve of the left hind limb in all experimental animals was damaged by crushing forceps for two minutes. In group one, the damaged nerve was left without any medical therapy, while in groups two and three, methylprednisolone and therankeron were used to treat the crushed sciatic nerve, respectively. The Clinical signs and histopathological changes depended on the 30th and 60th postoperative days to evaluate the degree of nerve repair. In group one, all animals did not use their affected limb with loss of sensation completely, while early and pronounced enhancement in the hind limb function was shown, especially in group three than in group two. In group one, the histopathological changes were characterized by the presence of areas of nerve fiber necrosis and disconnection of it, inflammatory cell infiltration with blood vessel congestion, and edema formation between the nerve fibers in both following periods. The same changes were shown in groups two and three, in addition to the presence of nerve fibers' regeneration, especially in group three, superior to group two. In conclusion, the results of this article revealed positive clinical and histopathological effects of both theranekron and methylprednisolone on the healing and regeneration of the crushed sciatic nerve, with priority for therankeron in dogs. |
| first_indexed | 2024-03-08T18:13:22Z |
| format | Article |
| id | doaj.art-188ed64a6c744215a5a3af4ca017d93b |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-03-08T18:13:22Z |
| publishDate | 2024-01-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-188ed64a6c744215a5a3af4ca017d93b2023-12-31T20:28:51ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552024-01-013811610.33899/ijvs.2023.138795.2842181351Comparison between two medical drugs' effect on the crushed sciatic nerve healing in dogsOsama H. Al-Hyani0Ahmed Kh. Ali1Ahmed M. Al-Saidya2Hana Kh. Ismail3Department of Surgery and Theriogenology, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Surgery and Theriogenology, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Pathology and Poultry, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Pathology and Poultry Disease, Collage of Veterinary Medicine, University of Mosul, Mosul, IraqThis article was conducted to evaluate the role of therankeron and methylprednisolone on the healing and regeneration process of the damaged sciatic nerve by crushing in dogs. Eighteen adult dogs were used. The animals were divided into three equal groups. The sciatic nerve of the left hind limb in all experimental animals was damaged by crushing forceps for two minutes. In group one, the damaged nerve was left without any medical therapy, while in groups two and three, methylprednisolone and therankeron were used to treat the crushed sciatic nerve, respectively. The Clinical signs and histopathological changes depended on the 30th and 60th postoperative days to evaluate the degree of nerve repair. In group one, all animals did not use their affected limb with loss of sensation completely, while early and pronounced enhancement in the hind limb function was shown, especially in group three than in group two. In group one, the histopathological changes were characterized by the presence of areas of nerve fiber necrosis and disconnection of it, inflammatory cell infiltration with blood vessel congestion, and edema formation between the nerve fibers in both following periods. The same changes were shown in groups two and three, in addition to the presence of nerve fibers' regeneration, especially in group three, superior to group two. In conclusion, the results of this article revealed positive clinical and histopathological effects of both theranekron and methylprednisolone on the healing and regeneration of the crushed sciatic nerve, with priority for therankeron in dogs.https://www.vetmedmosul.com/article_181351_d9ca65a459e92e369113581530c0a705.pdfnerve injurynerve regenerationmethylprednisolonetherankeron |
| spellingShingle | Osama H. Al-Hyani Ahmed Kh. Ali Ahmed M. Al-Saidya Hana Kh. Ismail Comparison between two medical drugs' effect on the crushed sciatic nerve healing in dogs Iraqi Journal of Veterinary Sciences nerve injury nerve regeneration methylprednisolone therankeron |
| title | Comparison between two medical drugs' effect on the crushed sciatic nerve healing in dogs |
| title_full | Comparison between two medical drugs' effect on the crushed sciatic nerve healing in dogs |
| title_fullStr | Comparison between two medical drugs' effect on the crushed sciatic nerve healing in dogs |
| title_full_unstemmed | Comparison between two medical drugs' effect on the crushed sciatic nerve healing in dogs |
| title_short | Comparison between two medical drugs' effect on the crushed sciatic nerve healing in dogs |
| title_sort | comparison between two medical drugs effect on the crushed sciatic nerve healing in dogs |
| topic | nerve injury nerve regeneration methylprednisolone therankeron |
| url | https://www.vetmedmosul.com/article_181351_d9ca65a459e92e369113581530c0a705.pdf |
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