Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study
ObjectiveTo predict the target of Seabuckthorn polysaccharides in the prevention and treatment of cervical cancer, and to explore its multi-target and multi-pathway mechanism.MethodsUsing the Swisstarget database, a total of 61 potential targets of polysaccharide active components were obtained. Cer...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1136590/full |
| _version_ | 1811168385426259968 |
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| author | Xuehua Feng Zurong Song Ali Tao Panpan Gong Wenqing Pei Rumin Zong |
| author_facet | Xuehua Feng Zurong Song Ali Tao Panpan Gong Wenqing Pei Rumin Zong |
| author_sort | Xuehua Feng |
| collection | DOAJ |
| description | ObjectiveTo predict the target of Seabuckthorn polysaccharides in the prevention and treatment of cervical cancer, and to explore its multi-target and multi-pathway mechanism.MethodsUsing the Swisstarget database, a total of 61 potential targets of polysaccharide active components were obtained. Cervical cancer related targets were obtained from the GeneCards database. The correlation score was greater than 5 targets for 2727; 15 intersection targets of active ingredients and disease were obtained by Venn diagram. Cytoscape3.6.0 software was used to construct the Polysaccharide composition-Target-Disease Network and Protein-Protein Interaction Networks (PPI). Cytoscape3.6.0 software was used for visualization and network topology analysis to obtain core targets. Kyoto encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) were analyzed using Metascape database. SailVina and PyMOL software were used for molecular docking to verify binding strength.ResultsA total of 15 core targets were obtained for cervical cancer. These targets are significantly enriched in HIF-1 signaling pathway, Galactose metabolism, EGFR tyrosine kinase inhibitor resistance, growth factor receptor binding, carbohydrate binding, protein homodimerization activity and other GO and KEGG entries; Molecular docking showed that ADA and GLB1 were well bound to Glucose, D-Mannose, and Galactose.ConclusionThe effect of seabuckthorn polysaccharides on the prevention and treatment of cervical cancer is characterized by multi-component, multi-target and multi-pathway, which provides scientific basis for further research on the activity of seabuckthorn polysaccharides. |
| first_indexed | 2024-04-10T16:25:26Z |
| format | Article |
| id | doaj.art-188f55c4a10744c6b3d27889169bb1ff |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T16:25:26Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-188f55c4a10744c6b3d27889169bb1ff2023-02-09T04:57:33ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-02-011010.3389/fnut.2023.11365901136590Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism studyXuehua FengZurong SongAli TaoPanpan GongWenqing PeiRumin ZongObjectiveTo predict the target of Seabuckthorn polysaccharides in the prevention and treatment of cervical cancer, and to explore its multi-target and multi-pathway mechanism.MethodsUsing the Swisstarget database, a total of 61 potential targets of polysaccharide active components were obtained. Cervical cancer related targets were obtained from the GeneCards database. The correlation score was greater than 5 targets for 2727; 15 intersection targets of active ingredients and disease were obtained by Venn diagram. Cytoscape3.6.0 software was used to construct the Polysaccharide composition-Target-Disease Network and Protein-Protein Interaction Networks (PPI). Cytoscape3.6.0 software was used for visualization and network topology analysis to obtain core targets. Kyoto encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) were analyzed using Metascape database. SailVina and PyMOL software were used for molecular docking to verify binding strength.ResultsA total of 15 core targets were obtained for cervical cancer. These targets are significantly enriched in HIF-1 signaling pathway, Galactose metabolism, EGFR tyrosine kinase inhibitor resistance, growth factor receptor binding, carbohydrate binding, protein homodimerization activity and other GO and KEGG entries; Molecular docking showed that ADA and GLB1 were well bound to Glucose, D-Mannose, and Galactose.ConclusionThe effect of seabuckthorn polysaccharides on the prevention and treatment of cervical cancer is characterized by multi-component, multi-target and multi-pathway, which provides scientific basis for further research on the activity of seabuckthorn polysaccharides.https://www.frontiersin.org/articles/10.3389/fnut.2023.1136590/fullseabuckthorn polysaccharidescervical cancernetwork pharmacologytarget pointmechanism of action |
| spellingShingle | Xuehua Feng Zurong Song Ali Tao Panpan Gong Wenqing Pei Rumin Zong Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study Frontiers in Nutrition seabuckthorn polysaccharides cervical cancer network pharmacology target point mechanism of action |
| title | Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study |
| title_full | Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study |
| title_fullStr | Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study |
| title_full_unstemmed | Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study |
| title_short | Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study |
| title_sort | prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study |
| topic | seabuckthorn polysaccharides cervical cancer network pharmacology target point mechanism of action |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1136590/full |
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