The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosis
Study aim: To investigate an association of the Toll-like receptor (TLR) gene polymorphisms with the risk of coronary artery disease (CAD). Materials and Methods: We recruited 702 consecutive Russian patients with CAD and 300 healthy blood donors who were residents of Western Siberia (Kemerovo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2015-09-01
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| Series: | Атеросклероз |
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| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/757/699 |
| _version_ | 1828073561336578048 |
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| author | A. V. Ponasenko M. V. Khutornaya A. G. Kutikhin I. I. Zhidkova A. S. Golovkin O. L. Barbarash |
| author_facet | A. V. Ponasenko M. V. Khutornaya A. G. Kutikhin I. I. Zhidkova A. S. Golovkin O. L. Barbarash |
| author_sort | A. V. Ponasenko |
| collection | DOAJ |
| description | Study aim: To investigate an association of the Toll-like receptor (TLR) gene polymorphisms with the risk of coronary artery disease (CAD). Materials and
Methods: We recruited 702 consecutive Russian patients with CAD and 300 healthy blood donors who were residents of Western Siberia (Kemerovo Region). We investigated eight polymorphisms within four genes: TLR1 (rs5743551, rs5743611), TLR2 (rs3804099, rs5743708), TLR4 (rs4986790, rs4986791), and TLR6 (rs3775073, rs5743810). Sample genotyping was performed in 96-well format using the TaqMan SNP genotyping assay.
Results: C/C genotype of rs5743551 polymorphism and C/G genotype of rs5743611 polymorphism within TLR1 gene along with T/C genotype of rs3775073 polymorphism and A/G genotype of rs5743810 polymorphism within TLR6 gene were associated with a high risk of coronary artery disease
(OR = 0.41 (95 % CI = 0.20–0.84), OR = 1.56, 95 % CI = 1.04–2.34, OR = 1.68, 95 % CI = 1.03–2.73, and OR = 1.55 (95 % CI = 1.12–2.14, р < 0,05, respectively) independently of age and gender.
Conclusions: certain Toll-like receptor gene polymorphisms are associated with the risk of CAD. |
| first_indexed | 2024-04-11T01:31:09Z |
| format | Article |
| id | doaj.art-188fd5a1a75c4a949a33409a099d8e71 |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:31:09Z |
| publishDate | 2015-09-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-188fd5a1a75c4a949a33409a099d8e712023-01-03T09:44:16ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2015-09-011132228The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosisA. V. Ponasenko0M. V. Khutornaya1A. G. Kutikhin2I. I. Zhidkova3A. S. Golovkin4O. L. Barbarash5Research Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationFederal North-West Medical Research Centre Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationStudy aim: To investigate an association of the Toll-like receptor (TLR) gene polymorphisms with the risk of coronary artery disease (CAD). Materials and Methods: We recruited 702 consecutive Russian patients with CAD and 300 healthy blood donors who were residents of Western Siberia (Kemerovo Region). We investigated eight polymorphisms within four genes: TLR1 (rs5743551, rs5743611), TLR2 (rs3804099, rs5743708), TLR4 (rs4986790, rs4986791), and TLR6 (rs3775073, rs5743810). Sample genotyping was performed in 96-well format using the TaqMan SNP genotyping assay. Results: C/C genotype of rs5743551 polymorphism and C/G genotype of rs5743611 polymorphism within TLR1 gene along with T/C genotype of rs3775073 polymorphism and A/G genotype of rs5743810 polymorphism within TLR6 gene were associated with a high risk of coronary artery disease (OR = 0.41 (95 % CI = 0.20–0.84), OR = 1.56, 95 % CI = 1.04–2.34, OR = 1.68, 95 % CI = 1.03–2.73, and OR = 1.55 (95 % CI = 1.12–2.14, р < 0,05, respectively) independently of age and gender. Conclusions: certain Toll-like receptor gene polymorphisms are associated with the risk of CAD.https://ateroskleroz.elpub.ru/jour/article/view/757/699coronary artery diseaseatherosclerosisinnate immunitytoll-like receptorsgene polymorphisms |
| spellingShingle | A. V. Ponasenko M. V. Khutornaya A. G. Kutikhin I. I. Zhidkova A. S. Golovkin O. L. Barbarash The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosis Атеросклероз coronary artery disease atherosclerosis innate immunity toll-like receptors gene polymorphisms |
| title | The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosis |
| title_full | The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosis |
| title_fullStr | The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosis |
| title_full_unstemmed | The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosis |
| title_short | The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosis |
| title_sort | role of polymorphisms within genes encoding toll like receptors in coronary atherosclerosis |
| topic | coronary artery disease atherosclerosis innate immunity toll-like receptors gene polymorphisms |
| url | https://ateroskleroz.elpub.ru/jour/article/view/757/699 |
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