Variational inference for detecting differential translation in ribosome profiling studies

Variational inference for detecting differential translation in ribosome profiling studies

Translational efficiency change is an important mechanism for regulating protein synthesis. Experiments with paired ribosome profiling (Ribo-seq) and mRNA-sequencing (RNA-seq) allow the study of translational efficiency by simultaneously quantifying the abundances of total transcripts and those that...

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Bibliographic Details
Main Authors: David C. Walker, Zachary R. Lozier, Ran Bi, Pulkit Kanodia, W. Allen Miller, Peng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Genetics
Subjects:
riboVI
variational inference
variational Bayes (VB)
ribosome profiling (Ribo-seq)
next-generation sequencing
RNA sequencing (RNA-seq)
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1178508/full

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