The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth
Summary The Hippo pathway has a central role in coordinating tissue growth and apoptosis. Mutations that compromise Hippo pathway activity cause tissue overgrowth and have been causally linked to cancer. In Drosophila, the transcriptional coactivator Yorkie mediates Hippo pathway activity to control...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2013-06-01
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| Series: | Biology Open |
| Subjects: | |
| Online Access: | http://bio.biologists.org/content/2/8/822 |
| _version_ | 1818436826060292096 |
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| author | Wei Zhang Stephen M. Cohen |
| author_facet | Wei Zhang Stephen M. Cohen |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | Summary
The Hippo pathway has a central role in coordinating tissue growth and apoptosis. Mutations that compromise Hippo pathway activity cause tissue overgrowth and have been causally linked to cancer. In Drosophila, the transcriptional coactivator Yorkie mediates Hippo pathway activity to control the expression of cyclin E and Myc to promote cell proliferation, as well as the expression of bantam miRNA and DIAP1 to inhibit cell death. Here we present evidence that the Hippo pathway acts via Yorkie and p53 to control the expression of the proapoptotic gene reaper. Yorkie further mediates reaper levels post-transcriptionally through regulation of members of the miR-2 microRNA family to prevent apoptosis. These findings provide evidence that the Hippo pathway acts via several distinct routes to limit proliferation-induced apoptosis. |
| first_indexed | 2024-12-14T17:14:57Z |
| format | Article |
| id | doaj.art-1891afacf38844b8954e8064f182250a |
| institution | Directory Open Access Journal |
| issn | 2046-6390 |
| language | English |
| last_indexed | 2024-12-14T17:14:57Z |
| publishDate | 2013-06-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Biology Open |
| spelling | doaj.art-1891afacf38844b8954e8064f182250a2022-12-21T22:53:26ZengThe Company of BiologistsBiology Open2046-63902013-06-012882282810.1242/bio.2013431720134317The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growthWei Zhang0Stephen M. Cohen1 Institute of Molecular Cell Biology, 61 Biopolis Drive, Singapore 138673 Institute of Molecular Cell Biology, 61 Biopolis Drive, Singapore 138673 Summary The Hippo pathway has a central role in coordinating tissue growth and apoptosis. Mutations that compromise Hippo pathway activity cause tissue overgrowth and have been causally linked to cancer. In Drosophila, the transcriptional coactivator Yorkie mediates Hippo pathway activity to control the expression of cyclin E and Myc to promote cell proliferation, as well as the expression of bantam miRNA and DIAP1 to inhibit cell death. Here we present evidence that the Hippo pathway acts via Yorkie and p53 to control the expression of the proapoptotic gene reaper. Yorkie further mediates reaper levels post-transcriptionally through regulation of members of the miR-2 microRNA family to prevent apoptosis. These findings provide evidence that the Hippo pathway acts via several distinct routes to limit proliferation-induced apoptosis.http://bio.biologists.org/content/2/8/822p53Hippo pathwayYorkie/YAPreaperMicroRNAApoptosisProliferation |
| spellingShingle | Wei Zhang Stephen M. Cohen The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth Biology Open p53 Hippo pathway Yorkie/YAP reaper MicroRNA Apoptosis Proliferation |
| title | The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth |
| title_full | The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth |
| title_fullStr | The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth |
| title_full_unstemmed | The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth |
| title_short | The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth |
| title_sort | hippo pathway acts via p53 and micrornas to control proliferation and proapoptotic gene expression during tissue growth |
| topic | p53 Hippo pathway Yorkie/YAP reaper MicroRNA Apoptosis Proliferation |
| url | http://bio.biologists.org/content/2/8/822 |
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