Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies
Neurogenic inflammation plays a significant role in the pathogenesis of migraines. This study aimed to investigate the serum levels of prostaglandin E2 (PGE2), lipoxin A4 (LXA4), and other inflammatory biomarkers (C-reactive protein, fibrinogen) in migraine patients. In total, 53 migraine patients a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/6/635 |
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| author | Idris Kocaturk Sedat Gulten Bunyamin Ece Fatma Mutlu Kukul Guven |
| author_facet | Idris Kocaturk Sedat Gulten Bunyamin Ece Fatma Mutlu Kukul Guven |
| author_sort | Idris Kocaturk |
| collection | DOAJ |
| description | Neurogenic inflammation plays a significant role in the pathogenesis of migraines. This study aimed to investigate the serum levels of prostaglandin E2 (PGE2), lipoxin A4 (LXA4), and other inflammatory biomarkers (C-reactive protein, fibrinogen) in migraine patients. In total, 53 migraine patients and 53 healthy controls were evaluated. Blood serum samples were collected during both attack and interictal periods and compared with the control group. In both the attack and interictal periods, PGE2 and LXA4 values were significantly lower in migraine patients compared to the control group (<i>p</i> < 0.001). Additionally, PGE2 values during the attack period were significantly higher than those during the interictal period (<i>p</i> = 0.016). Patients experiencing migraine attacks lasting ≥ 12 h had significantly lower serum PGE2 and LXA4 levels compared to those with attacks lasting < 12 h (<i>p</i> = 0.028 and <i>p</i> = 0.009, respectively). In ROC analysis, cut-off values of 332.7 pg/mL for PGE2 and 27.2 ng/mL for LXA4 were determined with 70–80% sensitivity and specificity. In conclusion, PGE2 and LXA4 levels are significantly lower in migraine patients during both interictal and attack periods. Additionally, the levels of LXA4 and PGE2 decrease more with the prolongation of migraine attack duration. Our findings provide a basis for future treatment planning. |
| first_indexed | 2024-04-24T18:23:08Z |
| format | Article |
| id | doaj.art-1892f68905eb4f7d800fbd16b5356255 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-24T18:23:08Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1892f68905eb4f7d800fbd16b53562552024-03-27T13:33:23ZengMDPI AGDiagnostics2075-44182024-03-0114663510.3390/diagnostics14060635Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based TherapiesIdris Kocaturk0Sedat Gulten1Bunyamin Ece2Fatma Mutlu Kukul Guven3Department of Neurology, Kastamonu University, Kastamonu 37150, TürkiyeDepartment of Biochemistry, Kastamonu University, Kastamonu 37150, TürkiyeDepartment of Radiology, Kastamonu University, Kastamonu 37150, TürkiyeDepartment of Emergency Medicine, Kastamonu University, Kastamonu 37150, TürkiyeNeurogenic inflammation plays a significant role in the pathogenesis of migraines. This study aimed to investigate the serum levels of prostaglandin E2 (PGE2), lipoxin A4 (LXA4), and other inflammatory biomarkers (C-reactive protein, fibrinogen) in migraine patients. In total, 53 migraine patients and 53 healthy controls were evaluated. Blood serum samples were collected during both attack and interictal periods and compared with the control group. In both the attack and interictal periods, PGE2 and LXA4 values were significantly lower in migraine patients compared to the control group (<i>p</i> < 0.001). Additionally, PGE2 values during the attack period were significantly higher than those during the interictal period (<i>p</i> = 0.016). Patients experiencing migraine attacks lasting ≥ 12 h had significantly lower serum PGE2 and LXA4 levels compared to those with attacks lasting < 12 h (<i>p</i> = 0.028 and <i>p</i> = 0.009, respectively). In ROC analysis, cut-off values of 332.7 pg/mL for PGE2 and 27.2 ng/mL for LXA4 were determined with 70–80% sensitivity and specificity. In conclusion, PGE2 and LXA4 levels are significantly lower in migraine patients during both interictal and attack periods. Additionally, the levels of LXA4 and PGE2 decrease more with the prolongation of migraine attack duration. Our findings provide a basis for future treatment planning.https://www.mdpi.com/2075-4418/14/6/635migraineinflammationprostaglandin E2lipoxin A4C-reactive proteinfibrinogen |
| spellingShingle | Idris Kocaturk Sedat Gulten Bunyamin Ece Fatma Mutlu Kukul Guven Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies Diagnostics migraine inflammation prostaglandin E2 lipoxin A4 C-reactive protein fibrinogen |
| title | Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies |
| title_full | Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies |
| title_fullStr | Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies |
| title_full_unstemmed | Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies |
| title_short | Exploring PGE2 and LXA4 Levels in Migraine Patients: The Potential of LXA4-Based Therapies |
| title_sort | exploring pge2 and lxa4 levels in migraine patients the potential of lxa4 based therapies |
| topic | migraine inflammation prostaglandin E2 lipoxin A4 C-reactive protein fibrinogen |
| url | https://www.mdpi.com/2075-4418/14/6/635 |
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