Adherence to Statin Therapy Among US Adults Between 2007 and 2014
Background Prior studies suggest that persistence with and adherence to statin therapy is low. Interventions to improve statin persistence and adherence have been developed over the past decade. Methods and Results This was a retrospective cohort study of adults aged ≥21 y with commercial or governm...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.118.010376 |
| _version_ | 1818775910648643584 |
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| author | Lisandro D. Colantonio Robert S. Rosenson Luqin Deng Keri L. Monda Yuling Dai Michael E. Farkouh Monika M. Safford Kiran Philip Katherine E. Mues Paul Muntner |
| author_facet | Lisandro D. Colantonio Robert S. Rosenson Luqin Deng Keri L. Monda Yuling Dai Michael E. Farkouh Monika M. Safford Kiran Philip Katherine E. Mues Paul Muntner |
| author_sort | Lisandro D. Colantonio |
| collection | DOAJ |
| description | Background Prior studies suggest that persistence with and adherence to statin therapy is low. Interventions to improve statin persistence and adherence have been developed over the past decade. Methods and Results This was a retrospective cohort study of adults aged ≥21 y with commercial or government health insurance in the MarketScan (Truven Health Analytics) and Medicare databases who initiated statins in 2007–2014 and (1) started treatment after a myocardial infarction (n=201 573), (2) had diabetes mellitus but without coronary heart disease (CHD; n=610 049), or (3) did not have CHD or diabetes mellitus (n=2 244 868). Persistence with (ie, not discontinuing treatment) and high adherence to statin therapy were assessed using pharmacy fills in the year following treatment initiation. In 2007 and 2014, the proportions of patients persistent with statin therapy were 78.1% and 79.1%, respectively, among those initiating treatment following myocardial infarction; 66.5% and 67.3%, respectively, for those with diabetes mellitus but without CHD; and 64.3% and 63.9%, respectively, for those without CHD or diabetes mellitus. Between 2007 and 2014, high adherence to statin therapy increased from 57.9% to 63.8% among patients initiating treatment following myocardial infarction and from 34.9% to 37.6% among those with diabetes mellitus but without CHD (each Ptrend<0.001). Among patients without CHD or diabetes mellitus, high adherence did not improve between 2007 (35.7%) and 2014 (36.8%; Ptrend=0.14). In 2014, statin adherence was lower among younger, black, and Hispanic patients versus white patients and those initiating a high‐intensity statin dosage. Statin adherence was higher among men and patients with cardiologist care following treatment initiation. Conclusions Persistence with and adherence to statin therapy remain low, particularly among those without CHD. |
| first_indexed | 2024-12-18T11:04:33Z |
| format | Article |
| id | doaj.art-1893555c6e7e490ba6210178685d9daa |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-18T11:04:33Z |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-1893555c6e7e490ba6210178685d9daa2022-12-21T21:10:08ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802019-01-018110.1161/JAHA.118.010376Adherence to Statin Therapy Among US Adults Between 2007 and 2014Lisandro D. Colantonio0Robert S. Rosenson1Luqin Deng2Keri L. Monda3Yuling Dai4Michael E. Farkouh5Monika M. Safford6Kiran Philip7Katherine E. Mues8Paul Muntner9Department of Epidemiology School of Public Health University of Alabama at Birmingham ALMount Sinai Heart Icahn School of Medicine at Mount Sinai New York NYDepartment of Epidemiology School of Public Health University of Alabama at Birmingham ALCenter for Observational Research Amgen Inc. Thousand Oaks CADepartment of Epidemiology School of Public Health University of Alabama at Birmingham ALPeter Munk Cardiac Centre and Heart and Stroke Richard Lewar Centre of Excellence University of Toronto Ontario CanadaDepartment of Medicine Weill Cornell Medical College New York NYMedical Affairs Amgen Inc. Thousand Oaks CACenter for Observational Research Amgen Inc. Thousand Oaks CADepartment of Epidemiology School of Public Health University of Alabama at Birmingham ALBackground Prior studies suggest that persistence with and adherence to statin therapy is low. Interventions to improve statin persistence and adherence have been developed over the past decade. Methods and Results This was a retrospective cohort study of adults aged ≥21 y with commercial or government health insurance in the MarketScan (Truven Health Analytics) and Medicare databases who initiated statins in 2007–2014 and (1) started treatment after a myocardial infarction (n=201 573), (2) had diabetes mellitus but without coronary heart disease (CHD; n=610 049), or (3) did not have CHD or diabetes mellitus (n=2 244 868). Persistence with (ie, not discontinuing treatment) and high adherence to statin therapy were assessed using pharmacy fills in the year following treatment initiation. In 2007 and 2014, the proportions of patients persistent with statin therapy were 78.1% and 79.1%, respectively, among those initiating treatment following myocardial infarction; 66.5% and 67.3%, respectively, for those with diabetes mellitus but without CHD; and 64.3% and 63.9%, respectively, for those without CHD or diabetes mellitus. Between 2007 and 2014, high adherence to statin therapy increased from 57.9% to 63.8% among patients initiating treatment following myocardial infarction and from 34.9% to 37.6% among those with diabetes mellitus but without CHD (each Ptrend<0.001). Among patients without CHD or diabetes mellitus, high adherence did not improve between 2007 (35.7%) and 2014 (36.8%; Ptrend=0.14). In 2014, statin adherence was lower among younger, black, and Hispanic patients versus white patients and those initiating a high‐intensity statin dosage. Statin adherence was higher among men and patients with cardiologist care following treatment initiation. Conclusions Persistence with and adherence to statin therapy remain low, particularly among those without CHD.https://www.ahajournals.org/doi/10.1161/JAHA.118.010376medication adherencestatin therapy |
| spellingShingle | Lisandro D. Colantonio Robert S. Rosenson Luqin Deng Keri L. Monda Yuling Dai Michael E. Farkouh Monika M. Safford Kiran Philip Katherine E. Mues Paul Muntner Adherence to Statin Therapy Among US Adults Between 2007 and 2014 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease medication adherence statin therapy |
| title | Adherence to Statin Therapy Among US Adults Between 2007 and 2014 |
| title_full | Adherence to Statin Therapy Among US Adults Between 2007 and 2014 |
| title_fullStr | Adherence to Statin Therapy Among US Adults Between 2007 and 2014 |
| title_full_unstemmed | Adherence to Statin Therapy Among US Adults Between 2007 and 2014 |
| title_short | Adherence to Statin Therapy Among US Adults Between 2007 and 2014 |
| title_sort | adherence to statin therapy among us adults between 2007 and 2014 |
| topic | medication adherence statin therapy |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.010376 |
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