Combination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy

Combination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy

Abstract Background Premature ovarian insufficiency (POI) is a major cause of infertility. In this study, we aimed to investigate the effects of the combination of bone marrow mesenchymal stem cells (BMSCs) and moxibustion (BMSCs-MOX) on POI and evaluate the underlying mechanisms. Methods A POI rat...

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Bibliographic Details
Main Authors: Ge Lu, Hong-xiao Li, Zi-wei Song, Jia Luo, Yan-liang Fan, Yao-li Yin, Jie Shen, Mei-hong Shen
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Stem Cell Research & Therapy
Subjects:
Premature ovarian insufficiency
Bone marrow mesenchymal stem cells
Moxibustion
Mitochondrial function
Mitophagy
Online Access:https://doi.org/10.1186/s13287-024-03709-0

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