The Anion Channel TMEM16a/Ano1 Modulates CFTR Activity, but Does Not Function as an Apical Anion Channel in Colonic Epithelium from Cystic Fibrosis Patients and Healthy Individuals

The Anion Channel TMEM16a/Ano1 Modulates CFTR Activity, but Does Not Function as an Apical Anion Channel in Colonic Epithelium from Cystic Fibrosis Patients and Healthy Individuals

Studies in human colonic cell lines and murine intestine suggest the presence of a Ca<sup>2+</sup>-activated anion channel, presumably TMEM16a. Is there a potential for fluid secretion in patients with severe cystic fibrosis transmembrane conductance regulator (<i>CFTR</i>) m...

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Bibliographic Details
Main Authors: Azam Salari, Renjie Xiu, Mahdi Amiri, Sophia Theres Pallenberg, Rainer Schreiber, Anna-Maria Dittrich, Burkhard Tümmler, Karl Kunzelmann, Ursula Seidler
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
cystic fibrosis
human colon
enteroids
colonoids
rectal organoids
Ussing chamber
Online Access:https://www.mdpi.com/1422-0067/24/18/14214

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