Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients

Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients

Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system. These proteins can be detected using the quaking-induced conversion assay. Compared with other bioassays, this assay is extremely sensitive and was used in the present study...

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Bibliographic Details
Main Authors: Hanae Takatsuki, PhD, Takayuki Fuse, PhD, Takehiro Nakagaki, MD, PhD, Tsuyoshi Mori, PhD, Ban Mihara, MD, PhD, Masaki Takao, MD, PhD, Yasushi Iwasaki, MD, PhD, Mari Yoshida, MD, PhD, Shigeo Murayama, MD, PhD, Ryuichiro Atarashi, MD, PhD, Noriyuki Nishida, MD, PhD, Katsuya Satoh, MD, PhD
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:EBioMedicine
Subjects:
Prion
Prion-seeding activity
SD50
Non-neural tissue
Creutzfeldt-Jakob disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416303887

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