Mechanosensitive Ion Channels and Their Role in Cancer Cells
Mechanical forces are an inherent element in the world around us. The effects of their action can be observed both on the macro and molecular levels. They can also play a prominent role in the tissues and cells of animals due to the presence of mechanosensitive ion channels (MIChs) such as the Piezo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/13/2/167 |
| _version_ | 1797619354920026112 |
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| author | Julia Karska Szymon Kowalski Jolanta Saczko Mihaela G. Moisescu Julita Kulbacka |
| author_facet | Julia Karska Szymon Kowalski Jolanta Saczko Mihaela G. Moisescu Julita Kulbacka |
| author_sort | Julia Karska |
| collection | DOAJ |
| description | Mechanical forces are an inherent element in the world around us. The effects of their action can be observed both on the macro and molecular levels. They can also play a prominent role in the tissues and cells of animals due to the presence of mechanosensitive ion channels (MIChs) such as the Piezo and TRP families. They are essential in many physiological processes in the human body. However, their role in pathology has also been observed. Recent discoveries have highlighted the relationship between these channels and the development of malignant tumors. Multiple studies have shown that MIChs mediate the proliferation, migration, and invasion of various cancer cells via various mechanisms. This could show MIChs as new potential biomarkers in cancer detection and prognosis and interesting therapeutic targets in modern oncology. Our paper is a review of the latest literature on the role of the Piezo1 and TRP families in the molecular mechanisms of carcinogenesis in different types of cancer. |
| first_indexed | 2024-03-11T08:27:00Z |
| format | Article |
| id | doaj.art-1898428d954542528996b43532b0b429 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-11T08:27:00Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-1898428d954542528996b43532b0b4292023-11-16T22:02:15ZengMDPI AGMembranes2077-03752023-01-0113216710.3390/membranes13020167Mechanosensitive Ion Channels and Their Role in Cancer CellsJulia Karska0Szymon Kowalski1Jolanta Saczko2Mihaela G. Moisescu3Julita Kulbacka4Faculty of Medicine, Wroclaw Medical University, 50-345 Wroclaw, PolandFaculty of Medicine, Wroclaw Medical University, 50-345 Wroclaw, PolandDepartment of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Biophysics and Cellular Biotechnology, Research Center of Excellence in Biophysics and Cellular Biotechnology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, PolandMechanical forces are an inherent element in the world around us. The effects of their action can be observed both on the macro and molecular levels. They can also play a prominent role in the tissues and cells of animals due to the presence of mechanosensitive ion channels (MIChs) such as the Piezo and TRP families. They are essential in many physiological processes in the human body. However, their role in pathology has also been observed. Recent discoveries have highlighted the relationship between these channels and the development of malignant tumors. Multiple studies have shown that MIChs mediate the proliferation, migration, and invasion of various cancer cells via various mechanisms. This could show MIChs as new potential biomarkers in cancer detection and prognosis and interesting therapeutic targets in modern oncology. Our paper is a review of the latest literature on the role of the Piezo1 and TRP families in the molecular mechanisms of carcinogenesis in different types of cancer.https://www.mdpi.com/2077-0375/13/2/167mechanosensitive ion channelspiezo channelsmechanoreceptorscancer |
| spellingShingle | Julia Karska Szymon Kowalski Jolanta Saczko Mihaela G. Moisescu Julita Kulbacka Mechanosensitive Ion Channels and Their Role in Cancer Cells Membranes mechanosensitive ion channels piezo channels mechanoreceptors cancer |
| title | Mechanosensitive Ion Channels and Their Role in Cancer Cells |
| title_full | Mechanosensitive Ion Channels and Their Role in Cancer Cells |
| title_fullStr | Mechanosensitive Ion Channels and Their Role in Cancer Cells |
| title_full_unstemmed | Mechanosensitive Ion Channels and Their Role in Cancer Cells |
| title_short | Mechanosensitive Ion Channels and Their Role in Cancer Cells |
| title_sort | mechanosensitive ion channels and their role in cancer cells |
| topic | mechanosensitive ion channels piezo channels mechanoreceptors cancer |
| url | https://www.mdpi.com/2077-0375/13/2/167 |
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