Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage
The progress of COVID-19 from moderate to severe may be precipitous, while the characteristics of the disease are heterogenous. The aim of this study was to describe the development of sinus bradycardia in critically ill patients with COVID-19 and its association with outcome in outbreak due to the...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750021001311 |
| _version_ | 1819101733046976512 |
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| author | Athanasios Chalkias Ioannis Pantazopoulos Nikolaos Papagiannakis Anargyros Skoulakis Eleni Laou Konstantina Kolonia Nicoletta Ntalarizou Konstantinos Tourlakopoulos Athanasios Pagonis Christos Kampolis Luis García De Guadiana Romualdo Dimitrios Ragias Jesper Eugen-Olsen Konstantinos Gourgoulianis Eleni Arnaoutoglou |
| author_facet | Athanasios Chalkias Ioannis Pantazopoulos Nikolaos Papagiannakis Anargyros Skoulakis Eleni Laou Konstantina Kolonia Nicoletta Ntalarizou Konstantinos Tourlakopoulos Athanasios Pagonis Christos Kampolis Luis García De Guadiana Romualdo Dimitrios Ragias Jesper Eugen-Olsen Konstantinos Gourgoulianis Eleni Arnaoutoglou |
| author_sort | Athanasios Chalkias |
| collection | DOAJ |
| description | The progress of COVID-19 from moderate to severe may be precipitous, while the characteristics of the disease are heterogenous. The aim of this study was to describe the development of sinus bradycardia in critically ill patients with COVID-19 and its association with outcome in outbreak due to the SARS-CoV-2 B.1.1.7 Lineage. We leveraged the multi-center SuPAR in Adult Patients With COVID-19 (SPARCOL) study and identified patients who required admission to intensive care unit (ICU). Inclusion criteria were: (a) adult (≥18 years old) patients hospitalized primarily for COVID-19; (b) a confirmed SARS-CoV-2 infection diagnosed through reverse transcriptase polymerase chain reaction test of nasopharyngeal or oropharyngeal samples; and (c) at least one blood sample collected at admission and stored for suPAR, hs-CRP, and ferritin testing. All patients had continuous heart rate monitoring during hospitalization. In total, 81 patients were included. Of them, 17 (21 %) and 64 (79 %) were intubated and admitted to the ICU during the first and second wave, respectively. Two (12 %) and 62 (97 %) developed bradycardia before ICU admission, respectively (p < 0.001). Patients with bradycardia had increased suPAR (p < 0.001) and hs-CRP level (p < 0.001). Infusion of isoprenaline and/or noradrenaline was necessary to maintain an adequate rate and peripheral perfusion in all patients. Mortality was significantly higher in patients with bradycardia (p < 0.001). In conclusion, bradycardia was associated with poor outcome. As B.1.1.7 variant strain is spreading more rapidly in many countries, our findings help in the identification of patients who may require early admission to ICU. |
| first_indexed | 2024-12-22T01:23:21Z |
| format | Article |
| id | doaj.art-189863f3dc664e6db01f95a776efcaab |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-22T01:23:21Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-189863f3dc664e6db01f95a776efcaab2022-12-21T18:43:40ZengElsevierToxicology Reports2214-75002021-01-01813941398Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 LineageAthanasios Chalkias0Ioannis Pantazopoulos1Nikolaos Papagiannakis2Anargyros Skoulakis3Eleni Laou4Konstantina Kolonia5Nicoletta Ntalarizou6Konstantinos Tourlakopoulos7Athanasios Pagonis8Christos Kampolis9Luis García De Guadiana Romualdo10Dimitrios Ragias11Jesper Eugen-Olsen12Konstantinos Gourgoulianis13Eleni Arnaoutoglou14University of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Anesthesiology, Larisa, Greece; Outcomes Research Consortium, Cleveland, OH, 44195, USA; Corresponding author at: University Hospital of Larisa, Department of Anesthesiology, 41110 Biopolis, Mezourlo, Larisa, Greece.University of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Emergency Medicine, Larisa, GreeceNational and Kapodistrian University of Athens, Medical School, Eginition University Hospital, First Department of Neurology, Athens, GreeceUniversity of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Anesthesiology, Larisa, GreeceUniversity of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Anesthesiology, Larisa, GreeceUniversity of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Anesthesiology, Larisa, GreeceUniversity of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Anesthesiology, Larisa, GreeceUniversity of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Respiratory Medicine, Larisa, GreeceUniversity of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Respiratory Medicine, Larisa, GreeceHippokrateion University Hospital, Department of Emergency Medicine, Athens, GreeceHospital Universitario Santa Lucía, Laboratory Medicine Department, Cartagena, SpainUniversity of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Anesthesiology, Larisa, GreeceCopenhagen University Hospital Hvidovre, Department of Clinical Research, Hvidovre, DenmarkUniversity of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Respiratory Medicine, Larisa, GreeceUniversity of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Anesthesiology, Larisa, GreeceThe progress of COVID-19 from moderate to severe may be precipitous, while the characteristics of the disease are heterogenous. The aim of this study was to describe the development of sinus bradycardia in critically ill patients with COVID-19 and its association with outcome in outbreak due to the SARS-CoV-2 B.1.1.7 Lineage. We leveraged the multi-center SuPAR in Adult Patients With COVID-19 (SPARCOL) study and identified patients who required admission to intensive care unit (ICU). Inclusion criteria were: (a) adult (≥18 years old) patients hospitalized primarily for COVID-19; (b) a confirmed SARS-CoV-2 infection diagnosed through reverse transcriptase polymerase chain reaction test of nasopharyngeal or oropharyngeal samples; and (c) at least one blood sample collected at admission and stored for suPAR, hs-CRP, and ferritin testing. All patients had continuous heart rate monitoring during hospitalization. In total, 81 patients were included. Of them, 17 (21 %) and 64 (79 %) were intubated and admitted to the ICU during the first and second wave, respectively. Two (12 %) and 62 (97 %) developed bradycardia before ICU admission, respectively (p < 0.001). Patients with bradycardia had increased suPAR (p < 0.001) and hs-CRP level (p < 0.001). Infusion of isoprenaline and/or noradrenaline was necessary to maintain an adequate rate and peripheral perfusion in all patients. Mortality was significantly higher in patients with bradycardia (p < 0.001). In conclusion, bradycardia was associated with poor outcome. As B.1.1.7 variant strain is spreading more rapidly in many countries, our findings help in the identification of patients who may require early admission to ICU.http://www.sciencedirect.com/science/article/pii/S2214750021001311COVID-19B.1.1.7 variantBradycardiaIntensive care unitOutcome |
| spellingShingle | Athanasios Chalkias Ioannis Pantazopoulos Nikolaos Papagiannakis Anargyros Skoulakis Eleni Laou Konstantina Kolonia Nicoletta Ntalarizou Konstantinos Tourlakopoulos Athanasios Pagonis Christos Kampolis Luis García De Guadiana Romualdo Dimitrios Ragias Jesper Eugen-Olsen Konstantinos Gourgoulianis Eleni Arnaoutoglou Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage Toxicology Reports COVID-19 B.1.1.7 variant Bradycardia Intensive care unit Outcome |
| title | Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage |
| title_full | Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage |
| title_fullStr | Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage |
| title_full_unstemmed | Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage |
| title_short | Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage |
| title_sort | sinus bradycardia is associated with poor outcome in critically ill patients with covid 19 due to the b 1 1 7 lineage |
| topic | COVID-19 B.1.1.7 variant Bradycardia Intensive care unit Outcome |
| url | http://www.sciencedirect.com/science/article/pii/S2214750021001311 |
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