Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid State
This review discusses the entire progress made on the anthelmintic drug praziquantel, focusing on the solid state and, therefore, on anhydrous crystalline polymorphs, amorphous forms, and multicomponent systems (i.e., hydrates, solvates, and cocrystals). Despite having been extensively studied over...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/1/27 |
| _version_ | 1827371284635320320 |
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| author | Ilenia D’Abbrunzo Giuseppe Procida Beatrice Perissutti |
| author_facet | Ilenia D’Abbrunzo Giuseppe Procida Beatrice Perissutti |
| author_sort | Ilenia D’Abbrunzo |
| collection | DOAJ |
| description | This review discusses the entire progress made on the anthelmintic drug praziquantel, focusing on the solid state and, therefore, on anhydrous crystalline polymorphs, amorphous forms, and multicomponent systems (i.e., hydrates, solvates, and cocrystals). Despite having been extensively studied over the last 50 years, new polymorphs and the greater part of their cocrystals have only been identified in the past decade. Progress in crystal engineering science (e.g., the use of mechanochemistry as a solid form screening tool and more strategic structure-based methods), along with the development of analytical techniques, including Synchrotron X-ray analyses, spectroscopy, and microscopy, have furthered the identification of unknown crystal structures of the drug. Also, computational modeling has significantly contributed to the prediction and design of new cocrystals by considering structural conformations and interactions energy. Whilst the insights on praziquantel polymorphs discussed in the present review will give a significant contribution to controlling their formation during manufacturing and drug formulation, the detailed multicomponent forms will help in designing and implementing future praziquantel-based functional materials. The latter will hopefully overcome praziquantel’s numerous drawbacks and exploit its potential in the field of neglected tropical diseases. |
| first_indexed | 2024-03-08T10:38:06Z |
| format | Article |
| id | doaj.art-1898c5df862640b29142a02f4fa7bd56 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-08T10:38:06Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-1898c5df862640b29142a02f4fa7bd562024-01-26T18:06:19ZengMDPI AGPharmaceutics1999-49232023-12-011612710.3390/pharmaceutics16010027Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid StateIlenia D’Abbrunzo0Giuseppe Procida1Beatrice Perissutti2Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, ItalyDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, ItalyDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, ItalyThis review discusses the entire progress made on the anthelmintic drug praziquantel, focusing on the solid state and, therefore, on anhydrous crystalline polymorphs, amorphous forms, and multicomponent systems (i.e., hydrates, solvates, and cocrystals). Despite having been extensively studied over the last 50 years, new polymorphs and the greater part of their cocrystals have only been identified in the past decade. Progress in crystal engineering science (e.g., the use of mechanochemistry as a solid form screening tool and more strategic structure-based methods), along with the development of analytical techniques, including Synchrotron X-ray analyses, spectroscopy, and microscopy, have furthered the identification of unknown crystal structures of the drug. Also, computational modeling has significantly contributed to the prediction and design of new cocrystals by considering structural conformations and interactions energy. Whilst the insights on praziquantel polymorphs discussed in the present review will give a significant contribution to controlling their formation during manufacturing and drug formulation, the detailed multicomponent forms will help in designing and implementing future praziquantel-based functional materials. The latter will hopefully overcome praziquantel’s numerous drawbacks and exploit its potential in the field of neglected tropical diseases.https://www.mdpi.com/1999-4923/16/1/27praziquantelsolid statecrystalline polymorphsamorphous formshydratessolvates |
| spellingShingle | Ilenia D’Abbrunzo Giuseppe Procida Beatrice Perissutti Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid State Pharmaceutics praziquantel solid state crystalline polymorphs amorphous forms hydrates solvates |
| title | Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid State |
| title_full | Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid State |
| title_fullStr | Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid State |
| title_full_unstemmed | Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid State |
| title_short | Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid State |
| title_sort | praziquantel fifty years on a comprehensive overview of its solid state |
| topic | praziquantel solid state crystalline polymorphs amorphous forms hydrates solvates |
| url | https://www.mdpi.com/1999-4923/16/1/27 |
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