N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin α5/β1/PI3K/AKT signaling

N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin α5/β1/PI3K/AKT signaling

Abstract Background Tendon injury is associated with oxidative stress, leading to reactive oxygen species (ROS) production and inflammation. N-acetyl-L-cysteine (NAC) is a potent antioxidant. However, how NAC affects the biological functions of tendon stem/progenitor cells (TSPCs) and tendon repair...

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Bibliographic Details
Main Authors: Kang Lu, Mei Zhou, Liyuan Wang, Yang Wang, Hong Tang, Gang He, Huan Wang, Chuyue Tang, Jie He, Wei Wang, Kanglai Tang, Yunjiao Wang, Zhongliang Deng
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Molecular and Cell Biology
Subjects:
NAC
TSPCs
Differentiation
Tendon injury
Rats
Online Access:https://doi.org/10.1186/s12860-022-00463-0

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