Nigericin Promotes NLRP3-Independent Bacterial Killing in Macrophages

Nigericin Promotes NLRP3-Independent Bacterial Killing in Macrophages

Altered microbiota has been associated with a number of diseases, including inflammatory bowel diseases, diabetes, and cancer. This dysregulation is thought to relate the host inflammatory response to enteric pathogens. Macrophages play a key role in host response to microbes and are involved in bac...

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Bibliographic Details
Main Authors: Heather Armstrong, Michael Bording-Jorgensen, Richard Chan, Eytan Wine
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
NLRP3
inflammasome
inflammatory bowel diseases
Citrobacter rodentium
nigericin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02296/full

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