Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway
Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets. However, the expression profile of lncRNAs and their role in melanoma progression...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.818178/full |
| _version_ | 1798020078503985152 |
|---|---|
| author | Jingjing Ma Qiong Shi Sen Guo Peng Xu Xiuli Yi Yuqi Yang Weigang Zhang Yu Liu Lin Liu Qiao Yue Tao Zhao Tianwen Gao Weinan Guo Chunying Li |
| author_facet | Jingjing Ma Qiong Shi Sen Guo Peng Xu Xiuli Yi Yuqi Yang Weigang Zhang Yu Liu Lin Liu Qiao Yue Tao Zhao Tianwen Gao Weinan Guo Chunying Li |
| author_sort | Jingjing Ma |
| collection | DOAJ |
| description | Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets. However, the expression profile of lncRNAs and their role in melanoma progression have not been thoroughly investigated. Herein, we firstly obtained the expression profile of lncRNAs in primary melanomas using microarray analysis and unveiled the differentially-expressed lncRNAs compared with nevus. Subsequently, a series of bioinformatics analysis showed the great involvement of dysregulated lncRNAs in melanoma biology and immune response. Further, we identified lncRNA CD27-AS1-208 as a novel nuclear-localized factor with prominent facilitative role in melanoma cell proliferation, invasion and migration. Mechanistically, CD27-AS1-208 could directly interact with STAT3 and contribute to melanoma progression in a STAT3-dependent manner. Ultimately, the role of CD27-AS1-208 in melanoma progression in vivo was also investigated. Collectively, the present study offers us a new horizon to better understand the role of lncRNAs in melanoma pathogenesis and demonstrates that CD27-AS1-208 up-regulation contributes to melanoma progression by activating STAT3 pathway. Targeting CD27-AS1-208 in melanoma cells can be exploited as a potential therapeutic approach that needs forward validation in clinical trials in the future. |
| first_indexed | 2024-04-11T16:51:49Z |
| format | Article |
| id | doaj.art-189be22462a647429892c77e1f9c039a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T16:51:49Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-189be22462a647429892c77e1f9c039a2022-12-22T04:13:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-01-011110.3389/fonc.2021.818178818178Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 PathwayJingjing MaQiong ShiSen GuoPeng XuXiuli YiYuqi YangWeigang ZhangYu LiuLin LiuQiao YueTao ZhaoTianwen GaoWeinan GuoChunying LiMelanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets. However, the expression profile of lncRNAs and their role in melanoma progression have not been thoroughly investigated. Herein, we firstly obtained the expression profile of lncRNAs in primary melanomas using microarray analysis and unveiled the differentially-expressed lncRNAs compared with nevus. Subsequently, a series of bioinformatics analysis showed the great involvement of dysregulated lncRNAs in melanoma biology and immune response. Further, we identified lncRNA CD27-AS1-208 as a novel nuclear-localized factor with prominent facilitative role in melanoma cell proliferation, invasion and migration. Mechanistically, CD27-AS1-208 could directly interact with STAT3 and contribute to melanoma progression in a STAT3-dependent manner. Ultimately, the role of CD27-AS1-208 in melanoma progression in vivo was also investigated. Collectively, the present study offers us a new horizon to better understand the role of lncRNAs in melanoma pathogenesis and demonstrates that CD27-AS1-208 up-regulation contributes to melanoma progression by activating STAT3 pathway. Targeting CD27-AS1-208 in melanoma cells can be exploited as a potential therapeutic approach that needs forward validation in clinical trials in the future.https://www.frontiersin.org/articles/10.3389/fonc.2021.818178/fullmelanomaLncRNAsCD27-AS1-208STAT3therapeutic targets |
| spellingShingle | Jingjing Ma Qiong Shi Sen Guo Peng Xu Xiuli Yi Yuqi Yang Weigang Zhang Yu Liu Lin Liu Qiao Yue Tao Zhao Tianwen Gao Weinan Guo Chunying Li Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway Frontiers in Oncology melanoma LncRNAs CD27-AS1-208 STAT3 therapeutic targets |
| title | Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway |
| title_full | Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway |
| title_fullStr | Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway |
| title_full_unstemmed | Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway |
| title_short | Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway |
| title_sort | long non coding rna cd27 as1 208 facilitates melanoma progression by activating stat3 pathway |
| topic | melanoma LncRNAs CD27-AS1-208 STAT3 therapeutic targets |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.818178/full |
| work_keys_str_mv | AT jingjingma longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT qiongshi longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT senguo longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT pengxu longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT xiuliyi longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT yuqiyang longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT weigangzhang longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT yuliu longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT linliu longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT qiaoyue longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT taozhao longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT tianwengao longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT weinanguo longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway AT chunyingli longnoncodingrnacd27as1208facilitatesmelanomaprogressionbyactivatingstat3pathway |