Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysis
Background: There is little evidence regarding the association between ambient air pollution and incidence and the mortality of pulmonary hypertension (PH). Methods: We included 494,750 participants at baseline in the UK Biobank study. Exposures to PM2.5, PM10, NO2, and NOx were estimated at geocode...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323006309 |
| _version_ | 1797744111779840000 |
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| author | Hui Shi Lan Chen Shiyu Zhang Rui Li Yinglin Wu Hongtao Zou Chongjian Wang Miao Cai Hualiang Lin |
| author_facet | Hui Shi Lan Chen Shiyu Zhang Rui Li Yinglin Wu Hongtao Zou Chongjian Wang Miao Cai Hualiang Lin |
| author_sort | Hui Shi |
| collection | DOAJ |
| description | Background: There is little evidence regarding the association between ambient air pollution and incidence and the mortality of pulmonary hypertension (PH). Methods: We included 494,750 participants at baseline in the UK Biobank study. Exposures to PM2.5, PM10, NO2, and NOx were estimated at geocoded participants' residential addresses, utilizing pollution data provided by UK Department for Environment, Food and Rural Affairs (DEFRA). The outcomes were the incidence and mortality of PH. We used multivariate multistate models to investigate the impacts of various ambient air pollutants on both incidence and mortality of PH. Results: During a median follow-up of 11.75 years, 2517 participants developed incident PH, and 696 died. We observed that all ambient air pollutants were associated with increased incidence of PH with different magnitudes, with adjusted hazard ratios (HRs) [95% confidence intervals (95% CIs)] for each interquartile range (IQR) increase of 1.73 (1.65, 1.81) for PM2.5, 1.70 (1.63, 1.78) for PM10, 1.42 (1.37, 1.48) for NO2, and 1.35 (1.31, 1.40) for NOx. Furthermore, PM2.5, PM10, NO2 and NO2 influenced the transition from PH to death, and the corresponding HRs (95% CIs) were 1.35 (1.25, 1.45), 1.31 (1.21, 1.41), 1.28 (1.20, 1.37) and 1.24 (1.17, 1.32), respectively. Conclusion: The results of our study indicate that exposure to various ambient air pollutants might play key but differential roles in both the incidence and mortality of PH. |
| first_indexed | 2024-03-12T15:05:03Z |
| format | Article |
| id | doaj.art-189bedf10a454e5e9a0f62f3c403d0b4 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-12T15:05:03Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-189bedf10a454e5e9a0f62f3c403d0b42023-08-13T04:51:41ZengElsevierEcotoxicology and Environmental Safety0147-65132023-09-01262115126Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysisHui Shi0Lan Chen1Shiyu Zhang2Rui Li3Yinglin Wu4Hongtao Zou5Chongjian Wang6Miao Cai7Hualiang Lin8Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; Correspondence to: Department of Epidemiology, School of Public Health, Sun Yat-sen University, NO. 74, Zhongshan 2rd road, Yuexiu District, Guangzhou, Guangdong 510080, China.Background: There is little evidence regarding the association between ambient air pollution and incidence and the mortality of pulmonary hypertension (PH). Methods: We included 494,750 participants at baseline in the UK Biobank study. Exposures to PM2.5, PM10, NO2, and NOx were estimated at geocoded participants' residential addresses, utilizing pollution data provided by UK Department for Environment, Food and Rural Affairs (DEFRA). The outcomes were the incidence and mortality of PH. We used multivariate multistate models to investigate the impacts of various ambient air pollutants on both incidence and mortality of PH. Results: During a median follow-up of 11.75 years, 2517 participants developed incident PH, and 696 died. We observed that all ambient air pollutants were associated with increased incidence of PH with different magnitudes, with adjusted hazard ratios (HRs) [95% confidence intervals (95% CIs)] for each interquartile range (IQR) increase of 1.73 (1.65, 1.81) for PM2.5, 1.70 (1.63, 1.78) for PM10, 1.42 (1.37, 1.48) for NO2, and 1.35 (1.31, 1.40) for NOx. Furthermore, PM2.5, PM10, NO2 and NO2 influenced the transition from PH to death, and the corresponding HRs (95% CIs) were 1.35 (1.25, 1.45), 1.31 (1.21, 1.41), 1.28 (1.20, 1.37) and 1.24 (1.17, 1.32), respectively. Conclusion: The results of our study indicate that exposure to various ambient air pollutants might play key but differential roles in both the incidence and mortality of PH.http://www.sciencedirect.com/science/article/pii/S0147651323006309Ambient air pollutionPulmonary hypertensionDynamic associationMultistate analysis |
| spellingShingle | Hui Shi Lan Chen Shiyu Zhang Rui Li Yinglin Wu Hongtao Zou Chongjian Wang Miao Cai Hualiang Lin Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysis Ecotoxicology and Environmental Safety Ambient air pollution Pulmonary hypertension Dynamic association Multistate analysis |
| title | Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysis |
| title_full | Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysis |
| title_fullStr | Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysis |
| title_full_unstemmed | Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysis |
| title_short | Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysis |
| title_sort | dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension a multistate trajectory analysis |
| topic | Ambient air pollution Pulmonary hypertension Dynamic association Multistate analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323006309 |
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