Design and Assessment of a Novel In Silico Approach for Developing a Next-Generation Multi-Epitope Universal Vaccine Targeting Coronaviruses

Design and Assessment of a Novel In Silico Approach for Developing a Next-Generation Multi-Epitope Universal Vaccine Targeting Coronaviruses

In the past two decades, there have been three coronavirus outbreaks that have caused significant economic and health crises. Biologists predict that more coronaviruses may emerge in the near future. Therefore, it is crucial to develop preventive vaccines that can effectively combat multiple coronav...

Full description

Bibliographic Details
Main Authors:	Muhammad Asif Rasheed, Sohail Raza, Wadi B. Alonazi, Muhammad Adnan Ashraf, Muhammad Tariq Navid, Irfana Aslam, Muhammad Nasir Iqbal, Sarfraz Ur Rahman, Muhammad Ilyas Riaz
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	Microorganisms
Subjects:	SARS-CoV-2 variants universal vaccine multi-epitope prevention bioinformatics
Online Access:	https://www.mdpi.com/2076-2607/11/9/2282

Similar Items

Antigen epitopes of animal coronaviruses: a mini-review
by: Mingjun Su, et al.
Published: (2023-05-01)

In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS
by: O. I. Krynina, et al.
Published: (2013-12-01)

An In Silico Deep Learning Approach to Multi-Epitope Vaccine Design: A Hepatitis E Virus Case Study
by: Aqsa Ikram, et al.
Published: (2023-03-01)

In Silico Epitope-Based Vaccine Prediction against Fungal Infection Aspergillosis
by: Anamika Basu
Published: (2022-07-01)

In silico designing of a multi-epitope vaccine against Burkholderia pseudomallei: reverse vaccinology and immunoinformatics
by: Muhammad Shahab, et al.
Published: (2022-07-01)

Contriving multi-epitope vaccine ensemble for monkeypox disease using an immunoinformatics approach
by: Shahkaar Aziz, et al.
Published: (2022-10-01)

Multi-Epitope-Based Vaccine Candidate for Monkeypox: An In Silico Approach
by: Sayed Aliul Hasan Abdi, et al.
Published: (2022-09-01)

In silico prediction of T- and B-cell epitopes in PmpD: First step towards to the design of a Chlamydia trachomatis vaccine
by: Romina Cecilia Russi, et al.
Published: (2018-04-01)

DENV-Mimetic Polymersome Nanoparticles Bearing Multi-Epitope Lipopeptides Antigen as the Next-Generation Dengue Vaccine
by: Nur Adilah Abdul Rahman, et al.
Published: (2022-01-01)

An Immunoinformatics Approach to Design a Potent Multi-Epitope Vaccine against Asia-1 Genotype of Crimean–Congo Haemorrhagic Fever Virus Using the Structural Glycoproteins as a Target
by: Syed Zawar Shah, et al.
Published: (2022-12-01)

In Silico Prediction of Continuous Epitopes on Human immunoglobulin Light Chains
by: Soheyla Rohani, et al.
Published: (2020-08-01)

Editorial: Epitope Discovery and Synthetic Vaccine Design
by: Clarisa Beatriz Palatnik-de-Sousa, et al.
Published: (2018-04-01)

In silico design of a multi-epitope vaccine against HPV16/18
by: Samira Sanami, et al.
Published: (2022-08-01)

Multi-epitopes vaccine design for surface glycoprotein against SARS-CoV-2 using immunoinformatic approach
by: Sarmad Frogh Arshad, et al.
Published: (2024-01-01)

Design of a Novel and Potent Multi-Epitope Chimeric Vaccine against Human Papillomavirus (HPV): An Immunoinformatics Approach
by: Muhammad Shahab, et al.
Published: (2023-05-01)

Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes
by: Minchao Li, et al.
Published: (2021-02-01)

Employing an immunoinformatics approach revealed potent multi-epitope based subunit vaccine for lymphocytic choriomeningitis virus
by: Muhammad Waqas, et al.
Published: (2023-02-01)

Improved computational epitope profiling using structural models identifies a broader diversity of antibodies that bind to the same epitope
by: Fabian C. Spoendlin, et al.
Published: (2023-09-01)

Humoral Epitope Spreading in Autoimmune Bullous Diseases
by: Dario Didona, et al.
Published: (2018-04-01)

Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach
by: M. Shaminur Rahman, et al.
Published: (2020-07-01)

Linear B-Cell Epitope Prediction for In Silico Vaccine Design: A Performance Review of Methods Available via Command-Line Interface
by: Kosmas A. Galanis, et al.
Published: (2021-03-01)

Immunoinformatics design of multivalent epitope vaccine against monkeypox virus and its variants using membrane-bound, enveloped, and extracellular proteins as targets
by: Muhammad Waqas, et al.
Published: (2023-01-01)

Prediction of Brucella omp25 and BLS antigens epitopes and their interaction with MHC molecules in sheep by in silico methods
by: hashem Honar Hadadan, et al.
Published: (2021-12-01)

In Silico Design of a Multivalent Epitope Vaccine Against SARS-CoV-2 for Iranian Populations
by: Faezeh Soltanveis, et al.
Published: (2021-11-01)

Immunoinformatics Study: Multi-Epitope Based Vaccine Design from SARS-CoV-2 Spike Glycoprotein
by: Ramadhita Umitaibatin, et al.
Published: (2023-02-01)

Revolutionizing the virulent protein Internalin a in Listeria monocytogenes and designing multi epitope-based vaccine via immunoinformatic approaches
by: Tariq Aziz, et al.
Published: (2024-12-01)

In silico structure analysis and epitope prediction of E3 CR1-beta protein of Human Adenovirus E for vaccine design
by: Noman Ibna Amin Patwary, et al.
Published: (2016-12-01)

In Silico and In Vivo Evaluation of SARS-CoV-2 Predicted Epitopes-Based Candidate Vaccine
by: Mahmoud M. Shehata, et al.
Published: (2021-10-01)

Massively-multiplexed epitope mapping techniques for viral antigen discovery
by: Diya Hu, et al.
Published: (2023-09-01)

Identification of Epitopes on Rhinovirus 89 Capsid Proteins Capable of Inducing Neutralizing Antibodies
by: Katarzyna Niespodziana, et al.
Published: (2022-05-01)

Vaccine Design from the Ensemble of Surface Glycoprotein Epitopes of SARS-CoV-2: An Immunoinformatics Approach
by: Noor Rahman, et al.
Published: (2020-07-01)

Epitope Identification in BEFV Gene for Detecting Effective Points
by: Shima Molazadeh, et al.
Published: (2022-03-01)

A T-Cell Epitope-Based Multi-Epitope Vaccine Designed Using Human HLA Specific T Cell Epitopes Induces a Near-Sterile Immunity against Experimental Visceral Leishmaniasis in Hamsters
by: Aryandra Arya, et al.
Published: (2021-09-01)

In silico characterization of Echinococcus granulosus paramyosin nucleotide sequence for the development of epitope vaccine against cystic echinococcosis
by: Lu Y.-J., et al.
Published: (2017-12-01)

Accurate determination of epitope for antibodies with unknown 3D structures
by: Shifa Tahir, et al.
Published: (2021-01-01)

In silico multi-epitope Bunyumwera virus vaccine to target virus nucleocapsid N protein
by: Kanaka Durga Devi Nelluri, et al.
Published: (2022-06-01)

Designing Multi‐Epitope Subunit Vaccine Candidate for Zika Virus Utilizing In silico Tools
by: Fatemeh Shams Moattar, et al.
Published: (2022-03-01)

In silico prediction of the epitopes for the immunogenic proteins present in Mycobacterium avium subsp. paratuberculosis
by: D SWATHI, et al.
Published: (2020-03-01)

Computational epitope binning reveals functional equivalence of sequence-divergent paratopes
by: Jarjapu Mahita, et al.
Published: (2022-01-01)

Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective Review
by: Rahul Chatterjee, et al.
Published: (2021-07-01)