The effect of seed location on functional connectivity: evidence from an image-based meta-analysis
IntroductionDefault mode network (DMN) is the most involved network in the study of brain development and brain diseases. Resting-state functional connectivity (rsFC) is the most used method to study DMN, but different studies are inconsistent in the selection of seed. To evaluate the effect of diff...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1120741/full |
| _version_ | 1797816091116830720 |
|---|---|
| author | Meng-Ting Li Jia-Wei Sun Lin-Lin Zhan Collins Opoku Antwi Ya-Ting Lv Xi-Ze Jia Jun Ren |
| author_facet | Meng-Ting Li Jia-Wei Sun Lin-Lin Zhan Collins Opoku Antwi Ya-Ting Lv Xi-Ze Jia Jun Ren |
| author_sort | Meng-Ting Li |
| collection | DOAJ |
| description | IntroductionDefault mode network (DMN) is the most involved network in the study of brain development and brain diseases. Resting-state functional connectivity (rsFC) is the most used method to study DMN, but different studies are inconsistent in the selection of seed. To evaluate the effect of different seed selection on rsFC, we conducted an image-based meta-analysis (IBMA).MethodsWe identified 59 coordinates of seed regions of interest (ROIs) within the default mode network (DMN) from 11 studies (retrieved from Web of Science and Pubmed) to calculate the functional connectivity; then, the uncorrected t maps were obtained from the statistical analyses. The IBMA was performed with the t maps.ResultsWe demonstrate that the overlap of meta-analytic maps across different seeds’ ROIs within DMN is relatively low, which cautions us to be cautious with seeds’ selection.DiscussionFuture studies using the seed-based functional connectivity method should take the reproducibility of different seeds into account. The choice of seed may significantly affect the connectivity results. |
| first_indexed | 2024-03-13T08:32:32Z |
| format | Article |
| id | doaj.art-189f741fe65f4991b7e8d576f5cb105b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T08:32:32Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-189f741fe65f4991b7e8d576f5cb105b2023-05-31T04:25:09ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-05-011710.3389/fnins.2023.11207411120741The effect of seed location on functional connectivity: evidence from an image-based meta-analysisMeng-Ting Li0Jia-Wei Sun1Lin-Lin Zhan2Collins Opoku Antwi3Ya-Ting Lv4Xi-Ze Jia5Jun Ren6School of Psychology, Zhejiang Normal University, Jinhua, ChinaDepartment of Clinical Neuroscience, Division of Neuro, Karolinska Institutet, Stockholm, SwedenSchool of Western Studies, Heilongjiang University, Harbin, ChinaSchool of Psychology, Zhejiang Normal University, Jinhua, ChinaCenter for Cognition and Brain Disorders, The Affiliated Hospital, Hangzhou Normal University, Hangzhou, ChinaSchool of Psychology, Zhejiang Normal University, Jinhua, ChinaSchool of Psychology, Zhejiang Normal University, Jinhua, ChinaIntroductionDefault mode network (DMN) is the most involved network in the study of brain development and brain diseases. Resting-state functional connectivity (rsFC) is the most used method to study DMN, but different studies are inconsistent in the selection of seed. To evaluate the effect of different seed selection on rsFC, we conducted an image-based meta-analysis (IBMA).MethodsWe identified 59 coordinates of seed regions of interest (ROIs) within the default mode network (DMN) from 11 studies (retrieved from Web of Science and Pubmed) to calculate the functional connectivity; then, the uncorrected t maps were obtained from the statistical analyses. The IBMA was performed with the t maps.ResultsWe demonstrate that the overlap of meta-analytic maps across different seeds’ ROIs within DMN is relatively low, which cautions us to be cautious with seeds’ selection.DiscussionFuture studies using the seed-based functional connectivity method should take the reproducibility of different seeds into account. The choice of seed may significantly affect the connectivity results.https://www.frontiersin.org/articles/10.3389/fnins.2023.1120741/fullseed-based functional connectivityseed selectionimage-based meta-analysisreproducibilitydefault mode network |
| spellingShingle | Meng-Ting Li Jia-Wei Sun Lin-Lin Zhan Collins Opoku Antwi Ya-Ting Lv Xi-Ze Jia Jun Ren The effect of seed location on functional connectivity: evidence from an image-based meta-analysis Frontiers in Neuroscience seed-based functional connectivity seed selection image-based meta-analysis reproducibility default mode network |
| title | The effect of seed location on functional connectivity: evidence from an image-based meta-analysis |
| title_full | The effect of seed location on functional connectivity: evidence from an image-based meta-analysis |
| title_fullStr | The effect of seed location on functional connectivity: evidence from an image-based meta-analysis |
| title_full_unstemmed | The effect of seed location on functional connectivity: evidence from an image-based meta-analysis |
| title_short | The effect of seed location on functional connectivity: evidence from an image-based meta-analysis |
| title_sort | effect of seed location on functional connectivity evidence from an image based meta analysis |
| topic | seed-based functional connectivity seed selection image-based meta-analysis reproducibility default mode network |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1120741/full |
| work_keys_str_mv | AT mengtingli theeffectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT jiaweisun theeffectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT linlinzhan theeffectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT collinsopokuantwi theeffectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT yatinglv theeffectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT xizejia theeffectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT junren theeffectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT mengtingli effectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT jiaweisun effectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT linlinzhan effectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT collinsopokuantwi effectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT yatinglv effectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT xizejia effectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis AT junren effectofseedlocationonfunctionalconnectivityevidencefromanimagebasedmetaanalysis |